Valproate
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type of chemical entity(en)![]() | |
Bayanai | |
Ƙaramin ɓangare na |
branched chain fatty acids(en)![]() |
Farawa | 1967 |
Gagarumin taron |
Dépakine case(en)![]() |
Conjugate base(en)![]() |
valproate(en)![]() |
Sinadaran dabara | C₈H₁₆O₂ |
Canonical SMILES(en)![]() | CCCC(CCC)C(=O)O |
World Health Organisation international non-proprietary name(en)![]() | valproic acid |
Found in taxon(en)![]() |
Valeriana officinalis(en)![]() |
Medical condition treated(en)![]() |
Cutar bipolar,early-onset Alzheimer's disease(en)![]() ![]() ![]() |
Ta jiki ma'amala da |
histone deacetylase 1(en)![]() ![]() |
Legal status (medicine)(en)![]() |
boxed warning(en)![]() |
Pregnancy category(en)![]() |
Australian pregnancy category D(en)![]() ![]() |
Valproate(VPA) davalproic acid,sodium valproate,davalproate semisodiumsiffofin magunguna ne da farko da ake amfani da su don magance farfadiya da cututtuka na bipolar da kuma hana ciwon kai.[1]Suna da amfani don rigakafin faɗuwar da cuta a cikin waɗanda ba su da faɗuwar rashi, faɗuwar ɓangarori, da faɗuwar gaba ɗaya.[1]Ana iya ba su ta hanyar jini ko ta baki, kuma nau'ikan kwamfutar hannu suna wanzu a cikin tsari mai tsayi da gajere.[1]
Illolin valproate na yau da kullun sun haɗa da tashin zuciya, amai, bacci, da bushewar baki.[1]Mummunan illa na iya haɗawa da gazawar hanta, don haka ana ba da shawarar saka idanu akai-akai na gwajin aikin hanta.[1]Sauran manyan haɗari sun haɗa da pancreatitis da ƙara haɗarinkashe kai.[1]An san Valproate yana haifar da mummunar rashin daidaituwa a cikin jarirai idan an sha a lokacin daukar ciki,[1][2]kuma saboda haka ba a ba da shawarar ba ga matan da suka kai shekarun haihuwa waɗanda ke da migraines.[1]
Ba a san takamaiman tsarin aikin Valproate ba.[1][3]Hanyoyin da aka tsara sun haɗa da rinjayar matakan GABA, toshe tashoshin sodium mai ƙarfin lantarki, da hana histone deacetylases.[4][5]Valproic acid fatty acid ne mai guntun sarka (SCFA) wanda aka yi daga valeric acid.[4]
An fara yin Valproate a cikin 1881 kuma ya fara amfani da magani a cikin 1962.[6]Yana cikin Jerin Mahimman Magunguna na Hukumar Lafiya ta Duniya.[7]Ana samunsa azaman magani na gama-gari.[1]Jimlar farashin a cikin ƙasashe masu tasowa kusan dalar Amurka 0.40 kowace rana kamar na 2015.[8]A Amurka, kuɗin da ake kashewa yana kusan dalar Amurka 1.30 a kowace rana kamar na 2019.[9]Ana sayar da shi a ƙarƙashin alamun alamunDepakote,da sauransu.[1]A cikin 2017, shi ne na 126th mafi yawan magunguna a Amurka, tare da magunguna fiye da miliyan biyar.[10][11]
Manazarta
[gyara sashe|gyara masomin]- ↑1.001.011.021.031.041.051.061.071.081.091.10"Valproic Acid".The American Society of Health-System Pharmacists.Archivedfrom the original on 2017-07-31.RetrievedOct 23,2015.
- ↑"Valproate banned without the pregnancy prevention programme".GOV.UK.Retrieved26 April2018.
- ↑Owens MJ, Nemeroff CB (2003). "Pharmacology of valproate".Psychopharmacol Bull.37 Suppl 2: 17–24.PMID14624230.
- ↑4.04.1Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE (April 2013)."Valproic acid pathway: pharmacokinetics and pharmacodynamics".Pharmacogenet. Genomics.23(4): 236–241.doi:10.1097/FPC.0b013e32835ea0b2.PMC3696515.PMID23407051.
- ↑"Valproic acid".DrugBank.University of Alberta. 29 July 2017.Archivedfrom the original on 31 July 2017.Retrieved30 July2017.
- ↑Scott, D.F. (1993).The history of epileptic therapy: an account of how medication was developed(1. publ. ed.). Carnforth u.a.: Parthenon Publ. Group. p. 131.ISBN9781850703914.
- ↑World Health Organization(2019).World Health Organization model list of essential medicines: 21st list 2019.Geneva: World Health Organization.hdl:10665/325771.WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ↑International Medical Products Price Guide(PDF)(2015 ed.). Management Sciences for Health. 2016. p. A-140.Retrieved23 February2020.
- ↑"NADAC as of 2019-11-27 | Data.Medicaid.gov".Centers for Medicare and Medicaid Services.Archived fromthe originalon 2020-07-11.Retrieved25 November2019.
- ↑"The Top 300 of 2020".ClinCalc.Retrieved11 April2020.
- ↑"Divalproex Sodium - Drug Usage Statistics".ClinCalc.Archived fromthe originalon 27 August 2021.Retrieved11 April2020.