EIF2AK4

EIF2AK4
Struktur yang tersedia
PDB	Pencarian Ortolog:PDBeRCSB
Daftar kode id PDB
	1UKX,4OTN
Pengidentifikasi
Alias	EIF2AK4,GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
ID eksternal	OMIM:609280MGI:1353427HomoloGene:40891GeneCards:EIF2AK4
Lokasi gen (Tikus)
Kr.	Kromosom 2 (tikus)
Akhir	118,305,715bp
Ontologi gen
Fungsi molekuler	•transferase activity; •nucleotide binding; •protein kinase activity; •tRNA binding; •kinase activity; •protein serine/threonine kinase activity; •RNA binding; •ATP binding; •eukaryotic translation initiation factor 2alpha kinase activity;
Komponen seluler	•sitoplasma; •polysome; •cytosolic ribosome;
Proses biologis	•positive regulation of translational initiation in response to starvation; •adaptive immune response; •negative regulation of neuron differentiation; •positive regulation of long-term synaptic potentiation; •positive regulation of adaptive immune response; •negative regulation of translational initiation in response to stress; •negative regulation of translational initiation; •Fosforilasi; •immune system process; •cellular response to UV; •cellular response to amino acid starvation; •negative regulation of CREB transcription factor activity; •regulation of feeding behavior; •belajar; •perkembangan sistem saraf; •viral translation; •neuron projection extension; •protein phosphorylation; •cellular response to cold; •long-term memory; •defense response to virus; •cellular response to leucine starvation; •eiF2alpha phosphorylation in response to endoplasmic reticulum stress; •induction by virus of host autophagy; •protein autophosphorylation; •Siklus sel; •negative regulation by host of viral genome replication; •GO:0022415 viral process; •regulation of translation; •regulation of translational initiation; •positive regulation of defense response to virus by host; •T cell activation involved in immune response; •DNA damage checkpoint signaling; •regulation of translational initiation by eIF2 alpha phosphorylation;
	Sumber:Amigo/QuickGO
Ortolog
	440275
	27103
	ENSG00000128829
	ENSMUSG00000005102
	Q9P2K8
	Q9QZ05
	NM_001013703
	NM_001177806; NM_013719; NM_001355383
	NP_001013725
	NP_001171277; NP_038747; NP_001342312
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Eukaryotic translation initiation factor 2-alpha kinase 4adalahenzimyang disandikan olehgenEIF2AK4dalam tubuh manusia.^[4]^[5]

Dalam kedokteran

Mutasi pada gen ini dapat memicuhipertensi paru.^[6]

Referensi

^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000005102-Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase".Eur J Biochem.265(2): 754–62.doi:10.1046/j.1432-1327.1999.00780.x.PMID 10504407.
^"Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".
^Eyries M, Montani D, Girerd B et al.EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension,Nat Genet, 2014;46:65–69

Artikel bertopikgenini adalah sebuahrintisan.Anda dapat membantu Wikipedia denganmengembangkannya.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000005102-Ensembl,May 2017

[2] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10504407-4] Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase".Eur J Biochem.265(2): 754–62.doi:10.1046/j.1432-1327.1999.00780.x.PMID 10504407.

[entrez-5] "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

[Eyries_2014-6] Eyries M, Montani D, Girerd B et al.EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension,Nat Genet, 2014;46:65–69

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