NEAT1

NEAT1
Thức biệt tử
Ký hào	NEAT1,LINC00084, NCRNA00084, TncRNA, VINC, nuclear paraspeckle assembly transcript 1 (non-protein coding), nuclear paraspeckle assembly transcript 1
Ngoại bộ ID	OMIM:612769GeneCards:NEAT1
Di vân tử の vị trí (ヒト)
Nhiễm sắc thể	11 phiên nhiễm sắc thể (ヒト)
Chung điểm	65,445,540bp
オルソログ
	283131
	n/a
	ENSG00000245532
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ウィキデータ
Duyệt lãm / biên tập ヒト

Nuclear Enriched Abundant Transcript 1 (NEAT1) は, toàn trường ~3.2kbのHạch Trường tỏa ノンコーディングRNAである ( RIKEN cDNA 2310043N10Rik ).ウイルスDụ đạo tính ノンコーディングRNA( VINC ) またはMENイプシロンRNAとも hô ばれる.Đa phát tính nội phân tiết tuyến thũng chứngDi vân tử tọa から転 tả される^[3]^[4]^[5]^[6].

NEAT1の phát hiện はマウス脳においてNhật bổn 脳 viêmウイルスおよびCuồng khuyển bệnhウイルスによる cảm nhiễm kỳ に dụ đạo される. NEAT1は sổ đa くの phi thần kinhTổ chứcおよび tế bào hệ において cấu thành đích に phát hiện している. NEAT1はパラスペックル(Anh ngữ bản)と hô ばれる đặc hữu の hạch cấu tạo に cục tại する^[7].NEAT1 RNAはP54nrbまたはNONO(Anh ngữ bản)と hô ばれるパラスペックルタンパク chấtと tương hỗ tác dụng し, これはパラスペックル hình thành に tất tu である. いくかの nghiên cứu は, NEAT1 RNAがパラスペックルの hình thành および duy trì に tất tu であることを chứng minh している. したがって, このノンコーディングRNAは hạch パラスペックルにおいて trọng yếu な cấu tạo đích dịch cát を hữu しているようにみえる^[8]^[9].

Xuất điển

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000245532-Ensembl,May 2017
^Human PubMed Reference:
^“Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses.”.J. Gen. Virol.84(Pt 7): 1729–35. (2003).doi:10.1099/vir.0.18826-0.PMID 12810866.
^“Identification and characterization of a virus-inducible non-coding RNA in mouse brain.”.J. Gen. Virol.87(Pt 7): 1991–5. (2006).doi:10.1099/vir.0.81768-0.PMID 16760401.
^“A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.”.BMC Genomics8:39. (2007).doi:10.1186/1471-2164-8-39.PMC 1800850.PMID 17270048.
^“Entrez Gene: nuclear paraspeckle assembly transcript 1 (non-protein coding)”.2018 niên 10 nguyệt 10 nhậtDuyệt lãm.
^“MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.”.Genome Res.19(3): 347–59. (2009).doi:10.1101/gr.087775.108.PMC 2661813.PMID 19106332.
^“MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.”.Proc. Natl. Acad. Sci. U.S.A.106(8): 2525–30. (2009).doi:10.1073/pnas.0807899106.PMC 2650297.PMID 19188602.
^“An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.”.Mol. Cell33(6): 717–26. (2009).doi:10.1016/j.molcel.2009.01.026.PMC 2696186.PMID 19217333.

Thôi tiến văn hiến

“A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.”.Genome Res.7(7): 725–35. (1997).doi:10.1101/gr.7.7.725.PMC 310681.PMID 9253601.
“Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.”.Nat. Cell Biol.13(1): 95–101. (2011).doi:10.1038/ncb2140.PMC 3007124.PMID 21170033.
Peyman JA (2001). “Mammalian expression cloning of two human trophoblast suppressors of major histocompatibility complex genes.”.Am. J. Reprod. Immunol.45(6): 382–92.doi:10.1111/j.8755-8920.2001.450603.x.PMID 11458881.
“Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes.”.Biochem. Biophys. Res. Commun.301(3): 718–24. (2003).doi:10.1016/S0006-291X(03)00028-7.PMID 12565840.
“Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.”.Mol. Cell35(4): 467–78. (2009).doi:10.1016/j.molcel.2009.06.027.PMC 2749223.PMID 19716791.
Peyman JA (1999). “Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid.”.Biol. Reprod.60(1): 23–31.doi:10.1095/biolreprod60.1.23.PMID 9858482.

Quan liên hạng mục

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000245532-Ensembl,May 2017

[2] Human PubMed Reference:

[pmid12810866-3] “Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses.”.J. Gen. Virol.84(Pt 7): 1729–35. (2003).doi:10.1099/vir.0.18826-0.PMID 12810866.

[pmid16760401-4] “Identification and characterization of a virus-inducible non-coding RNA in mouse brain.”.J. Gen. Virol.87(Pt 7): 1991–5. (2006).doi:10.1099/vir.0.81768-0.PMID 16760401.

[pmid17270048-5] “A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.”.BMC Genomics8:39. (2007).doi:10.1186/1471-2164-8-39.PMC 1800850.PMID 17270048.

[entrez-6] “Entrez Gene: nuclear paraspeckle assembly transcript 1 (non-protein coding)”.2018 niên 10 nguyệt 10 nhậtDuyệt lãm.

[pmid19106332-7] “MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.”.Genome Res.19(3): 347–59. (2009).doi:10.1101/gr.087775.108.PMC 2661813.PMID 19106332.

[pmid19188602-8] “MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.”.Proc. Natl. Acad. Sci. U.S.A.106(8): 2525–30. (2009).doi:10.1073/pnas.0807899106.PMC 2650297.PMID 19188602.

[pmid19217333-9] “An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.”.Mol. Cell33(6): 717–26. (2009).doi:10.1016/j.molcel.2009.01.026.PMC 2696186.PMID 19217333.

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