FG-7142
FG-7142,siveZK-31906,estmedicamentumquodagonistae inversoadallostericumbenzodiazepinisitumreceptoris GABAApartim prodest.[1]Inter eius effectusphysiologicossuntanorexia,[2]anxiogenia,etconvulsiones.[3]Acetylcholinumetnoradrenalinumliberanda auget,[4]etmemoriasretinendas in studiisanimaliumemendat.[5]
Notae
[recensere|fontem recensere]- ↑"Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions".Synapse61(8): 646–63.2007.
- ↑"FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability".Neuropsychopharmacology32(5): 1069–81. Maius2007.
- ↑"Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABAAreceptor: neurochemical, neurophysiological, and behavioral effects ".CNS Drug Reviews13(4): 475–501. hiems2007.
- ↑"Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat".Neuroscience141(3): 1481–8.2006
- ↑"GABAAreceptors determine the temporal dynamics of memory retention ".Learning and Memory15(3): 106–11.2008.