Siklosporin

Siklosporin
Data klinikal
Sebutan	/ˌsaɪkləˈspɔːrɪn/
Nama dagang	Neoral, Sandimmune, lain-lain
Nama lain	siklosporin, siklosporin A,siklosporina A, siklosporin A (CsA), cyclosporine (USANAS)
AHFS/Drugs.com	Monograph
MedlinePlus	a601207
Datalesen	EUEMA:by INN;
Kategori; kehamilan	AU:C; ;
Kaedah; pemberian	Mulut,IV,titisan mata
Kelas ubat	imunosupresan; perencat kalsineurin; perubatan mata
Kod ATC	L04AD01(WHO)S01XA18;
Status perundangan
Status perundangan	AU:S4(Preskripsi sahaja); UK:POM(Preskripsi sahaja); AS:Rx sahaja;
Datafarmakokinetik
Bioketersediaan	Pelbagai
Metabolisme	CYP3A4hati
Penyingkiranseparuh hayat	Pelbagai (kira-kira 24 jam)
Perkumuhan	Hempedu
Pengecam
	Nama IUPAC (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33- [(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl] -6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl- 1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;
Nombor CAS	59865-13-3;
PubChemCID	5284373;
IUPHAR/BPS	1024;
DrugBank	DB00091;
ChemSpider	4447449;
UNII	83HN0GTJ6D;
KEGG	D00184;
ChEMBL	ChEMBL160;
CompTox Dashboard(EPA)	DTXSID0020365;
ECHA InfoCard	100.119.569
Data kimia dan fizikal
Formula	C62H111N11O12
Jisim molar	1202.61 g/mol
Model 3D (JSmol)	Gambar interaktif;
	SMILES CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H] (C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C) C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C;
	InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1; Key:PMATZTZNYRCHOR-CGLBZJNRSA-N;
	(what is this?)(verify)

Siklosporinatausiklosporinamerupakan ubat imunosuppresan dan produk asli.^[3]Ia diambil melalui mulut atau olehsuntikan dalam pembuluh darahuntukartritis reumatoid,psoriasis,penyakit Crohn, sindrom nefrotik, dantransplantasi organuntuk mencegah penolakan.^[4]Ia juga digunakan sebagai ubat penitis mata untuk keratokonjunktivitis sicca (mata kering).^[5]

Rujukan

^"cyclosporin".Dictionary.com Unabridged.Random House.n.d. Diarkibkan daripadayang asalpada 2010-11-18.Dicapai pada2011-07-13.Unknown parameter|deadurl=ignored (bantuan)
^Laupacis A, Keown PA, Ulan RA, McKenzie N, Stiller CR (May 1982)."Cyclosporin A: a powerful immunosuppressant".Canadian Medical Association Journal.126(9): 1041–6.PMC1863293.PMID 7074504.
^WHO Model Formulary 2008(PDF).World Health Organization. 2009. m/s. 221.ISBN 9789241547659.Diarkibkan daripadayang asal(PDF)pada 13 December 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)
^"Cyclosporine".The American Society of Health-System Pharmacists. Diarkibkan daripadayang asalpada 17 October 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)
^"Cyclosporine eent".The American Society of Health-System Pharmacists. Diarkibkan daripadayang asalpada 13 January 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)

Pautan luar

[1] "cyclosporin".Dictionary.com Unabridged.Random House.n.d. Diarkibkan daripadayang asalpada 2010-11-18.Dicapai pada2011-07-13.Unknown parameter|deadurl=ignored (bantuan)

[2] Laupacis A, Keown PA, Ulan RA, McKenzie N, Stiller CR (May 1982)."Cyclosporin A: a powerful immunosuppressant".Canadian Medical Association Journal.126(9): 1041–6.PMC1863293.PMID 7074504.

[WHO2008-3] WHO Model Formulary 2008(PDF).World Health Organization. 2009. m/s. 221.ISBN 9789241547659.Diarkibkan daripadayang asal(PDF)pada 13 December 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)

[AHFS2016-4] "Cyclosporine".The American Society of Health-System Pharmacists. Diarkibkan daripadayang asalpada 17 October 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)

[AHFS2016B-5] "Cyclosporine eent".The American Society of Health-System Pharmacists. Diarkibkan daripadayang asalpada 13 January 2016.Dicapai pada8 December2016.Unknown parameter|dead-url=ignored (bantuan)

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