Antiparazitar

Antiparazitarelealcătuiesc o clasă demedicamenteantimicrobiene indicate în tratamentul bolilor parazitare, cauzate dehelminți,^[1]amibe,^[2]ectoparaziți,fungi paraziți^[3]^[4]șiprotozoare.^[1]Antiparazitare pot să acționeze prin distrugerea paraziților (paraziticide) sau prin inhibarea creșterii lor.^[5]Căile de administrareutilizate în tratamentul bolilor parazitare sunt orală, intravenoasă și topică.^[5]

Clasificare

Cu spectru larg

Nitazoxanidă^[6]^[7]^[8]^[9]

Antiprotozoarice

Articol principal:Antiprotozoaric.

Chinină(pentru tratamentulmalariei)
Melarsoprol(pentrutripanosomiaza africanăcauzată deTrypanosoma brucei)
Eflornitină(pentru tripanosomiaza africană)
Metronidazol(pentruvaginităcauzată deTrichomonas)
Tinidazol(pentru infecții intestinale cauzate deGiardia lamblia)
Miltefosină(pentru tratamentulleishmaniozei)

Antihelmintice

Articol principal:Antihelmintic.

Antinematode

Mebendazol(pentru nematodoze)
Pamoat de pirantel(pentru nematodoze)
Pamoat de pirviniu(pentruoxiuroză)
Tiabendazol(pentru nematodoze)
Dietilcarbamazină(pentru filarioze limfatice)
Ivermectină(pentru profilaxiaoncocercozei)

Anticestode

Niclosamidă(pentru cestodoze)
Praziquantel(pentru cestodoze)
Albendazol(spectru larg)

Antitrematode

Praziquantel

Antiamoebiene

Note

^^a ^bKappagoda, Shanthi; Singh, Upinder; Blackburn, Brian G. (2011).„Antiparasitic Therapy”.Mayo Clin. Proc.86(6): 561–583.doi:10.4065/mcp.2011.0203.PMC3104918 .PMID 21628620.
^Kusrini E, Hashim F, Azmi WN, Amin NM, Estuningtyas A (2016). „A novel antiamoebic agent against Acanthamoeba sp. - A causative agent for eye keratitis infection”.Spectrochim Acta a Mol Biomol Spectrosc.153:714–21.doi:10.1016/j.saa.2015.09.021.PMID 26474244.
^Molina JM, Tourneur M, Sarfati C et al. (iunie 2002).„Fumagillin treatment of intestinal microsporidiosis”.N. Engl. J. Med.346(25): 1963–9.doi:10.1056/NEJMoa012924.PMID 12075057.
^Lanternier F, Boutboul D, Menotti J et al. (februarie 2009). „Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review”.Transpl Infect Dis.11(1): 83–8.doi:10.1111/j.1399-3062.2008.00347.x.PMID 18803616.
^^a ^b„ANTIPARASITICS”.Purdue University Cytology Laboratories.Purdue Research Foundation.Accesat în30 august 2015.
^Di Santo N, Ehrisman J (2013).„Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?”.Cancers (Basel).5(3): 1163–1176.doi:10.3390/cancers5031163.PMC3795384 .PMID 24202339.Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths.
^White CA (2004). „Nitazoxanide: a new broad spectrum antiparasitic agent”.Expert Rev Anti Infect Ther.2(1): 43–9.doi:10.1586/14787210.2.1.43.PMID 15482170.
^Hemphill A, Mueller J, Esposito M (2006). „Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections”.Expert Opin Pharmacother.7(7): 953–64.doi:10.1517/14656566.7.7.953.PMID 16634717.
^Anderson, V. R.; Curran, M. P. (2007). „Nitazoxanide: A review of its use in the treatment of gastrointestinal infections”.Drugs.67(13): 1947–1967.doi:10.2165/00003495-200767130-00015.PMID 17722965.

Vezi și

Antibiotic

[AT-1] Kappagoda, Shanthi; Singh, Upinder; Blackburn, Brian G. (2011).„Antiparasitic Therapy”.Mayo Clin. Proc.86(6): 561–583.doi:10.4065/mcp.2011.0203.PMC3104918 .PMID 21628620.

[pmid26474244-2] Kusrini E, Hashim F, Azmi WN, Amin NM, Estuningtyas A (2016). „A novel antiamoebic agent against Acanthamoeba sp. - A causative agent for eye keratitis infection”.Spectrochim Acta a Mol Biomol Spectrosc.153:714–21.doi:10.1016/j.saa.2015.09.021.PMID 26474244.

[pmid12075057-3] Molina JM, Tourneur M, Sarfati C et al. (iunie 2002).„Fumagillin treatment of intestinal microsporidiosis”.N. Engl. J. Med.346(25): 1963–9.doi:10.1056/NEJMoa012924.PMID 12075057.

[pmid18803616-4] Lanternier F, Boutboul D, Menotti J et al. (februarie 2009). „Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review”.Transpl Infect Dis.11(1): 83–8.doi:10.1111/j.1399-3062.2008.00347.x.PMID 18803616.

[Purdue-5] „ANTIPARASITICS”.Purdue University Cytology Laboratories.Purdue Research Foundation.Accesat în30 august 2015.

[Thiazolides-6] Di Santo N, Ehrisman J (2013).„Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?”.Cancers (Basel).5(3): 1163–1176.doi:10.3390/cancers5031163.PMC3795384 .PMID 24202339.Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths.

[Nitazoxanide:_Broad-spectrum_antiparasitic-7] White CA (2004). „Nitazoxanide: a new broad spectrum antiparasitic agent”.Expert Rev Anti Infect Ther.2(1): 43–9.doi:10.1586/14787210.2.1.43.PMID 15482170.

[Thiazolides:_Broad-spectrum-8] Hemphill A, Mueller J, Esposito M (2006). „Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections”.Expert Opin Pharmacother.7(7): 953–64.doi:10.1517/14656566.7.7.953.PMID 16634717.

[NTZ_2007_review-9] Anderson, V. R.; Curran, M. P. (2007). „Nitazoxanide: A review of its use in the treatment of gastrointestinal infections”.Drugs.67(13): 1947–1967.doi:10.2165/00003495-200767130-00015.PMID 17722965.

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