CCL19
| edit |
| Hemokin (C-C motiv) ligand 19 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | CCL19;CKb11; ELC; MGC34433; MIP-3b; MIP3B; SCYA19 | ||||||||||
| Vanjski ID | OMIM:602227MGI:1346316HomoloGene:4569GeneCards:CCL19 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6363 | 24047 | |||||||||
| Ensembl | ENSG00000172724 | n/a | |||||||||
| UniProt | Q99731 | n/a | |||||||||
| RefSeq (mRNA) | NM_006274 | NM_011888 | |||||||||
| RefSeq (protein) | NP_006265 | NP_036018 | |||||||||
| Lokacija (UCSC) | Chr 9: 34.68 - 34.68 Mb | n/a | |||||||||
| PubMedpretraga | [1] | [2] | |||||||||
CCL19,hemokin (C-C motiv) ligand 19,jeproteinkoji je kod ljudi kodiranCCL19genom.[1][2]CCL19 ja malicitokiniz CChemokinfamilije koji je takođe poznat kaoEBI1 ligand hemokin(ELC) imakrofagni inflamatorni protein-3-beta(MIP-3-beta).[3]
Ovajgenje jedan od nekoliko CC citokinskih gena grupisanih na p-rucihromozoma 9[4]Ovaj hemokin dejstvuje na svoje ciljne ćelije vezivanjem zahemokinski receptorCCR7.[5].Citokinisu familija izlučenih proteina koji učestvuju u imunoregulatornim i inflamatornim procesima. CC citokini suproteinikarakterisani sa dva susednacisteina.Za citokin kodiran ovim genom se veruje da igra ulogu u normalnoj recirkulacijilimfocita.On takođe ima važnu ulogu u razmeniT ćelijautimusu,i u migraciji T ćelija i B ćelija u sekundarne limfoidne organe. On se specifično vezuje za hemokinski receptorCCR7.[2]
CCL19 je obilno izražen utimusuilimfnim čvorovima,u umerenim nivoima utrahejiikolonu,i u niskim nivoima u stomaku,tankim crevima,plućima,bubrezimaislezini.[5]On privlači određene ćelijeimunskog sistema,kao što sudendritske ćelijei antigen-aktiviraneB ćelije,[6][7]CCR7+efektorske-memorijske T-ćelije.[8]
- ↑Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”.J Biol Chem272(21): 13803–9.DOI:10.1074/jbc.272.21.13803.PMID9153236.
- ↑2,02,1„Entrez Gene: CCL19 chemokine (C-C motif) ligand 19”.
- ↑Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998).Cytokines (Handbook of Immunopharmacology).Boston: Academic Press.ISBN0-12-498340-5.
- ↑Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997).„Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta”.J. Immunol.158(3): 1033–6.PMID9013939.
- ↑5,05,1Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”.J. Biol. Chem.272(21): 13803–9.DOI:10.1074/jbc.272.21.13803.PMID9153236.
- ↑Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). „The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes”.Cell103(5): 757–68.DOI:10.1016/S0092-8674(00)00179-3.PMID11114332.
- ↑Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). „Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position”.Nature416(6876): 94–9.DOI:10.1038/416094a.PMID11882900.
- ↑Bromley SK, Thomas SY, Luster AD (2005). „Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics”.Nat. Immunol.6(9): 895–901.DOI:10.1038/ni1240.PMID16116469.
- Weber C, Koenen RR (2006).„Fine-tuning leukocyte responses: towards a chemokine 'interactome'.”.Trends Immunol.27(6): 268–73.DOI:10.1016/j.it.2006.04.002.PMID16678487.
- Rossi DL, Vicari AP, Franz-Bacon K,et al.(1997). „Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.”.J. Immunol.158(3): 1033–6.PMID9013939.
- Nagira M, Imai T, Hieshima K,et al.(1997). „Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.”.J. Biol. Chem.272(31): 19518–24.DOI:10.1074/jbc.272.31.19518.PMID9235955.
- Kim CH, Pelus LM, White JR,et al.(1998). „CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.”.J. Immunol.160(5): 2418–24.PMID9498785.
- Yanagihara S, Komura E, Nagafune J,et al.(1998). „EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation.”.J. Immunol.161(6): 3096–102.PMID9743376.
- Gosling J, Dairaghi DJ, Wang Y,et al.(2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.”.J. Immunol.164(6): 2851–6.PMID10706668.
- Annunziato F, Romagnani P, Cosmi L,et al.(2000). „Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.”.J. Immunol.165(1): 238–46.PMID10861057.
- Ueno T, Hara K, Willis MS,et al.(2002). „Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.”.Immunity16(2): 205–18.DOI:10.1016/S1074-7613(02)00267-4.PMID11869682.
- Phillips R, Ager A (2002). „Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells.”.Eur. J. Immunol.32(3): 837–47.DOI:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q.PMID11870628.
- Till KJ, Lin K, Zuzel M, Cawley JC (2002). „The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.”.Blood99(8): 2977–84.DOI:10.1182/blood.V99.8.2977.PMID11929789.
- Townson JR, Nibbs RJ (2002). „Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.”.Eur. J. Immunol.32(5): 1230–41.DOI:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L.PMID11981810.
- Page G, Lebecque S, Miossec P (2002). „Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium.”.J. Immunol.168(10): 5333–41.PMID11994492.
- Katou F, Ohtani H, Nakayama T,et al.(2003).„Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin.”.J. Pathol.199(1): 98–106.DOI:10.1002/path.1255.PMID12474232.
- Strausberg RL, Feingold EA, Grouse LH,et al.(2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.DOI:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Scandella E, Men Y, Legler DF,et al.(2004). „CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2.”.Blood103(5): 1595–601.DOI:10.1182/blood-2003-05-1643.PMID14592837.
- Corcione A, Arduino N, Ferretti E,et al.(2004). „CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells.”.Clin. Cancer Res.10(3): 964–71.DOI:10.1158/1078-0432.CCR-1182-3.PMID14871974.
- Daikoku N, Kitaya K, Nakayama T,et al.(2004). „Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle.”.Fertil. Steril.81 Suppl 1:876–81.DOI:10.1016/j.fertnstert.2003.09.036.PMID15019823.
- Gerhard DS, Wagner L, Feingold EA,et al.(2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14(10B): 2121–7.DOI:10.1101/gr.2596504.PMC528928.PMID15489334.
- Paoletti S, Petkovic V, Sebastiani S,et al.(2005). „A rich chemokine environment strongly enhances leukocyte migration and activities.”.Blood105(9): 3405–12.DOI:10.1182/blood-2004-04-1648.PMID15546958.