AMPA

AMPA
	2-amino-3-(5-metil-3-okso-1,2-; oksazol-4-il)propanoinska kiselina
Identifikacija
CAS registarski broj	77521-29-0
PubChem	1221
ChemSpider	1184
DrugBank	DB02057
KEGG	C11033
MeSH	AMPA
ChEMBL	CHEMBL276815
Jmol-3D slike	Slika 1
SMILES
	O=C1/C(=C(\ON1)C)CC(N)C(=O)O
InChI
	InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12); Kod: UUDAMDVQRQNNHZ-UHFFFAOYSA-N InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12); Kod: UUDAMDVQRQNNHZ-UHFFFAOYAT
Svojstva
Molekulska formula	C7H10N2O4
Molarna masa	186.17 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanje (25 °C, 100 kPa)materijala
	Infobox references

AMPA(2-amino-3-(5-metil-3-okso-1,2-oksazol-4-il)propanoinska kiselina) jejedinjenjekoje je specifičanagonistzaAMPA receptor.AMPA oponaša dejstvoneurotransmitera glutamata.^[6]

Postoje dva tipa jonotropnih glutamatnih receptora koji suligandom kontrolisani jonski kanali.Njihovi agonisti su AMPA,kainatiNMDA.U sinapsama ove dve klase receptora služe za veoma različite svrhe. AMPA se može koristiti za eksperimentalno razlikovanje aktivnosti jednog tipa receptora od drugog da bi se razumela njihova funkcija.^[7]AMPA generiše brzeekscitatorne postsinaptičke potencijale(EPSP).^[6]AMPA activiraAMPA receptorekoji su neselektivni katjonski kanali. Oni omogućavaju prolaz Na+ i K+ i stoga imaju ravnotežni potencijal blizo 0 mV.

Reference

↑Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit
↑Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit
↑^6,0^6,1Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008).Neuroscience. 4th ed..Sinauer Associates. str. 128–33.ISBN 978-0-87893-697-7.
↑Dinh L, Nguyen T, Salgado H, Atzori M (2009). „Norepinephrine homogeneously inhibits Alpha -amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat”.Neurochem Res34(11): 1896–906.DOI:10.1007/s11064-009-9966-z.PMID 19357950.

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit

[4] Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit

[Purves2008-6] 6,0^6,1Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008).Neuroscience. 4th ed..Sinauer Associates. str. 128–33.ISBN 978-0-87893-697-7.

[Dinh2009-7] Dinh L, Nguyen T, Salgado H, Atzori M (2009). „Norepinephrine homogeneously inhibits Alpha -amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat”.Neurochem Res34(11): 1896–906.DOI:10.1007/s11064-009-9966-z.PMID 19357950.

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