Arotinolol
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(IUPAC) ime | |||
---|---|---|---|
(RS)-5-(2[3-(tert-butilamino)-2-hidroksipropil]sulfanil 1,3-tiazol-4-il)tiofen-2-karboksamid | |||
Klinički podaci | |||
AHFS/Drugs | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 41287-43-8 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 2239 | ||
ChemSpider[3] | 2152 | ||
UNII | 394E3P3B99 | ||
KEGG[4] | D07465 | ||
ChEMBL[5] | CHEMBL93298 | ||
Hemijski podaci | |||
Formula | C15H21N3O2S3 | ||
Mol. masa | 371,54 g/mol | ||
SMILES | eMolekuli&PubHem | ||
| |||
Farmakokinetičkipodaci | |||
Bioraspoloživost | 2 h | ||
Poluvreme eliminacije | 10 h | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | ℞Prescription only | ||
Način primene | Oralno |
Arotinolol(Almarl) jeleku klasi mešovitih alfa/beta blokatora.[6]
On se koristi za tretmanvisokog krvnog pritiska.[7]Predloženo je da se on može koristiti za treatmanesencijalnog tremora.[8]
- ↑Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID20970519.
- ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
- ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID20331846.
- ↑Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID21948594.
- ↑Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001).„Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes”.Can. J. Physiol. Pharmacol.79(7): 585–93.DOI:10.1139/cjpp-79-7-585.PMID11478592.
- ↑Wu H, Zhang Y, Huang J,et al.(September 2001).„Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers”.Hypertens. Res.24(5): 605–10.DOI:10.1291/hypres.24.605.PMID11675958.-Scholar search}}
- ↑Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003).„A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor”.Parkinsonism Relat. Disord.9(6): 341–7.DOI:10.1016/S1353-8020(03)00029-4.PMID12853233.
- Almarl アルマールArhivirano2012-02-16 naWayback Machine-u(PDF)
- Official Dainippon Sumitomo Pharma WebsiteArhivirano2020-07-01 naWayback Machine-u