Hinolon
(Preusmjereno sa straniceFluorohinolon)
Hinolonje familijasintetičkihantibiotikaširokog spektra[1][2][3]Prva generacija hinolona je počela uvođenjemnalidiksinske kiselnetokom1962za lečenjeinfekcija urinarnog traktakod ljudi.[4]Nalidiksinsku kiselinu je otkrio Džordž Lešer sa saradnicima tokom pokušaja sinteze hlorohina.[5]
Oni sprečavaju odvijanje i dupliranje bakterijskeDNK.[6]
Hinoloni, u poređenju sa drugim klasama antibiotika, nose veći rizik od kolonizacije saMRSAiClostridium difficile.[7][8][9]Večina hinolona u kliničkoj upotrebi pripada grupifluorohinolona,koji imaju atomfluoravezan za centralni prsten, tipično u poziciji 6, ili na C-7.
- ↑Andriole, VT The Quinolones. Academic Press, 1989.
- ↑Andersson, MI, MacGowan, AP. Development of the quinolones. J. Antimicrob. Chemother. (2003) 51, Suppl. S1, 1–11 DOI: 10.1093/jac/dkg212.
- ↑Ivanov DV, Budanov SV (2006). „[Ciprofloxacin and antibacterial therapy of respiratory tract infections]” (Russian).Antibiot. Khimioter.51(5): 29–37.PMID17310788.
- ↑sanofi-aventis U.S. LLC (September 2008).„NegGram Caplets (nalidixic acid, USP)”(PDF). USA: FDA.
- ↑Wentland MP: In memoriam: George Y. Lesher, Ph.D., in Hooper DC, Wolfson JS (eds): Quinolone antimicrobial agents, ed 2., Washington DC, American Society for Microbiology: XIII - XIV, 1993.
- ↑Hooper, DC. (March 2001).„Emerging mechanisms of fluoroquinolone resistance”(PDF).Emerg Infect Dis7(2): 337–41.DOI:10.3201/eid0702.010239.PMC2631735.PMID11294736.
- ↑Muto, CA.; Jernigan, JA.; Ostrowsky, BE.; Richet, HM.; Jarvis, WR.; Boyce, JM.; Farr, BM. (May 2003).„SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus”.Infect Control Hosp Epidemiol24(5): 362–86.DOI:10.1086/502213.PMID12785411.
- ↑Dr Ralf-Peter Vonberg.„Clostridium difficile: a challenge for hospitals”.European Center for Disease Prevention and Control.Institute for Medical Microbiology and Hospital Epidemiology: IHE. Arhivirano izoriginalana datum 2009-06-11.Pristupljeno 27. 7. 2009.
- ↑Tacconelli, E.; De Angelis, G.; Cataldo, MA.; Pozzi, E.; Cauda, R. (January 2008).„Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis”.J Antimicrob Chemother61(1): 26–38.DOI:10.1093/jac/dkm416.PMID17986491.