Iproklozid

Iproklozid
(IUPAC) ime
	2-(4-hlorofenoksi)-N'-izopropil-acetohidrazid
Klinički podaci
Identifikatori
CAS broj	3544-35-2
ATC kod	N06AF06
PubChem	19063
ChemSpider	17998
UNII	1II9D6CB3J
KEGG	D07338
ChEMBL	CHEMBL91238
Hemijski podaci
Formula	C11H15ClN2O2
Mol. masa	242,70 g/mol
SMILES	eMolekuli&PubHem
InChI
	InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15); Key: GGECDTUJZOXAAR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Uncontrolled
Način primene	Oralno

Iproklozid(Sursum,Sinderezin) jeireverzibilniiselektivni inhibitor monoaminske oksidaze(MAOI) izhidrazinske hemijske klasekoji je korišten kaoantidepresiv,ali je njegova primena prekinuta.^[6]Poznato je da ovaj lek može da uzrokujehepatitisi bilo je najmanje tri smrtna slučaja uzrokovana njegovom upotrebom.^[7]^[8]

Reference

↑Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit
↑Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit
↑Suerinck A, Suerinck E. (1966). „[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]”.Journal de médecine de Lyon47(96): 573–586.PMID 5930723.
↑Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). „Iproclozide fulminant hepatitis. Possible role of enzyme induction.”.Gastroenterology.75(3): 492–496.PMID 680506.
↑Neil Kaplowitz, Laurie D. DeLeve (2003).Drug-induced liver disease.Informa Health Care. str.455.ISBN 9780824708115.

Povezano

Hidrazin (antidepresiv)

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit

[4] Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit

[pmid5930723-6] Suerinck A, Suerinck E. (1966). „[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]”.Journal de médecine de Lyon47(96): 573–586.PMID 5930723.

[pmid680506-7] Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). „Iproclozide fulminant hepatitis. Possible role of enzyme induction.”.Gastroenterology.75(3): 492–496.PMID 680506.

[bookDrug-induced_liver_disease-8] Neil Kaplowitz, Laurie D. DeLeve (2003).Drug-induced liver disease.Informa Health Care. str.455.ISBN 9780824708115.

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