RDS-127

RDS-127
(IUPAC) ime
	4,7-dimetoksi-N,N-dipropil-2,3-dihidro-1H-inden-2-amin
Klinički podaci
Identifikatori
CAS broj	82668-32-4
ATC kod	nije dodeljen
PubChem	134064
Hemijski podaci
Formula	C17H27NO2
Mol. masa	277,402 g/mol
SMILES	eMolekuli&PubHem
InChI
	InChI=1S/C17H27NO2/c1-5-9-18(10-6-2)13-11-14-15(12-13)17(20-4)8-7-16(14)19-3/h7-8,13H,5-6,9-12H2,1-4H3; Key: FPAHQTSJKYIURQ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

RDS-127jelekkoji se koristi u naučnim istraživanjima. On deluje kaoagonist D₂sličnih receptora,^[3]a manifestuje iserotoninskeiadrenergičkeefekte,^[4]^[5]^[6]^[7]kao iantiholinergičkodejstvo.^[8]^[9]U životinjskim studijama on pokazujeanoreksičnodejstvo i stimuliše seksualni nagon.^[10]^[11]

Reference

↑Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
↑Arnerić SP, Long JP, Williams M,et al.(January 1983).„RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”.The Journal of Pharmacology and Experimental Therapeutics224(1): 161–70.PMID 6401334.
↑Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). „Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives”.Archives Internationales De Pharmacodynamie et De Thérapie257(2): 263–73.PMID 7114973.
↑Arnerić SP, Long JP (May 1984). „Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions”.The Journal of Pharmacy and Pharmacology36(5): 318–21.PMID 6145768.
↑Clark JT, Smith ER (1986). „Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior”.Physiology & Behavior37(1): 47–52.DOI:10.1016/0031-9384(86)90382-3.PMID 3737722.
↑Rezaki YE, Ilhan M (1991). „Evaluation of Alpha -adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae”.Archives Internationales De Pharmacodynamie et De Thérapie310:76–86.PMID 1685313.
↑Sahin I, Ilhan M (1988). „The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig”.Archives Internationales De Pharmacodynamie et De Thérapie296:163–72.PMID 2907277.
↑Sahin I, Tuncer M, Ilhan M (March 1990). „Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice”.Archives Internationales De Physiologie et De Biochimie98(1): 7–9.DOI:10.3109/13813459009115730.PMID 1692697.
↑Arnerić SP, Roetker A, Long JP (September 1982). „Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists”.Neuropharmacology21(9): 885–90.DOI:10.1016/0028-3908(82)90080-6.PMID 6897285.
↑Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986).„Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and Alpha 2-adrenergic receptors”.Behavioral Neuroscience100(5): 664–8.DOI:10.1037/0735-7044.100.5.664.PMID 2877677.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.

[pmid6401334-3] Arnerić SP, Long JP, Williams M,et al.(January 1983).„RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”.The Journal of Pharmacology and Experimental Therapeutics224(1): 161–70.PMID 6401334.

[pmid7114973-4] Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). „Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives”.Archives Internationales De Pharmacodynamie et De Thérapie257(2): 263–73.PMID 7114973.

[pmid6145768-5] Arnerić SP, Long JP (May 1984). „Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions”.The Journal of Pharmacy and Pharmacology36(5): 318–21.PMID 6145768.

[pmid3737722-6] Clark JT, Smith ER (1986). „Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior”.Physiology & Behavior37(1): 47–52.DOI:10.1016/0031-9384(86)90382-3.PMID 3737722.

[pmid1685313-7] Rezaki YE, Ilhan M (1991). „Evaluation of Alpha -adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae”.Archives Internationales De Pharmacodynamie et De Thérapie310:76–86.PMID 1685313.

[pmid2907277-8] Sahin I, Ilhan M (1988). „The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig”.Archives Internationales De Pharmacodynamie et De Thérapie296:163–72.PMID 2907277.

[pmid1692697-9] Sahin I, Tuncer M, Ilhan M (March 1990). „Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice”.Archives Internationales De Physiologie et De Biochimie98(1): 7–9.DOI:10.3109/13813459009115730.PMID 1692697.

[pmid6897285-10] Arnerić SP, Roetker A, Long JP (September 1982). „Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists”.Neuropharmacology21(9): 885–90.DOI:10.1016/0028-3908(82)90080-6.PMID 6897285.

[pmid2877677-11] Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986).„Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and Alpha 2-adrenergic receptors”.Behavioral Neuroscience100(5): 664–8.DOI:10.1037/0735-7044.100.5.664.PMID 2877677.

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