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Spiramid

Izvor: Wikipedija
Spiramid
(IUPAC) ime
8-[3-(4-Fluorofenoksi)propil]-1-fenil-1,3,8-triazaspiro[4,5]dekan-4-o
Klinički podaci
Identifikatori
CAS broj 510-74-7
ATC kod nije dodeljen
PubChem[1][2] 68186
UNII 471LF4O004DaY
Hemijski podaci
Formula C22H27FN3O2
Mol. masa 384,466 g/mol
SMILES eMolekuli&PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Spiramid(AMI-193) jeselektivniantagonist5-HT2A,5-HT1A,iD2receptor.On ima neznatanafinitetza5-HT2Creceptor.[3][4][5]

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID20970519.edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
  3. Czoty PW, Howell LL (October 2000).„Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey”.Pharmacology, Biochemistry, and Behavior67(2): 257–64.DOI:10.1016/S0091-3057(00)00321-X.PMID11124389.
  4. Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G (November 2004). „A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone”.Progress in Neuro-psychopharmacology & Biological Psychiatry28(7): 1117–27.DOI:10.1016/j.pnpbp.2004.05.046.PMID15610924.
  5. Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I (November 2007). „Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice”.Journal of Pharmacological Sciences105(3): 240–50.DOI:10.1254/jphs.FP0071049.PMID17965538.

Spoljašnje veze

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