Hipoksantin

Hipoksantin
	1H-purin-6(9H)-one
Identifikacija
CAS registarski broj	68-94-0
PubChem	790
ChemSpider	768
UNII	2TN51YD919
KEGG	C00262
MeSH	Hypoxanthine
ChEBI	17368
ChEMBL	CHEMBL1427
Jmol-3D slike	Slika 1
SMILES
	c1[nH]c2c(n1)[nH]cnc2=O
InChI
	InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10); Kod: FDGQSTZJBFJUBT-UHFFFAOYSA-N InChI=1/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10); Kod: FDGQSTZJBFJUBT-UHFFFAOYAJ
Svojstva
Molekulska formula	C5H4N4O
Molarna masa	136.112
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanje (25 °C, 100 kPa)materijala
	Infobox references

Hipoksantinjepurinskiderivat. On se ponekad nalazi kao sastojaknukleinskih kiselinagde je prisutan uantikodonu tRNKu obliku Njegovog nukleozidainozina.On ima tautomer poznat kao 6-Hidroksipurin.^[6]Hipoksantin je neophodan dodatak u pojedinim ćelijama, bakterijama, i parazitskim kulturama kao supstrat i izvor azota. Na primer, on je često neophodan reagens u malarijskim parazitskim kulturama, pošto je zaPlasmodium falciparumneophodan izvor hipoksantina za sintezu nuklenskih kiselina i za energetski metabolizam.

Avgusta2011,objavljen je izveštaj baziran naNASAispitivanjimameteoritanađenih naZemljikoji sugeriše da je ksantin i srodniorganski molekuli,među kojima su komponenteDNKiRNK:adeniniguanin,možda mogu da budi formirani ektraterestrijalno usvemiru.^[7]^[8]

Reakcije

Hipoksantin je jedan od proizvodaksantinske oksidazenaksantinskomsupstratu. On se češće formirapurinskom degradacijom.

Hipoksantin-guanin fosforibosiltransferazakonvertuje hipoksantin uIMPtokomnukleotidnog spasavanja.

Hipoksantin se takođe spontano formiradeaminacijom adenina.Zbog njegove sličnosti saguaninom,spontanadeaminacijaadenina može da dovede do greške uDNK transkripciji/replikaciji.

Literatura

↑Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit
↑Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit
↑Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002).Molecular Biology of the Cell.New York: Garlard Science.ISBN 0-8153-3218-1.
↑Steigerwald, John (8. 8. 2011.).„NASA Researchers: DNA Building Blocks Can Be Made in Space”.NASA.Arhivirano izoriginalana datum 2020-05-11.Pristupljeno 10. 8. 2011.
↑ScienceDaily Staff (9. 8. 2011.).„DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests”.ScienceDaily.Pristupljeno 9. 8. 2011.

Spoljašnje veze

Portal Hemija

MeSHHypoxanthine

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID 20970519.edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID 20331846.edit

[4] Joanne Wixon, Douglas Kell (2000).„Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”.Yeast17(1): 48–55.DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”.Nucleic Acids Res40(Database issue): D1100-7.DOI:10.1093/nar/gkr777.PMID 21948594.edit

[6] Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002).Molecular Biology of the Cell.New York: Garlard Science.ISBN 0-8153-3218-1.

[Steigerwald-7] Steigerwald, John (8. 8. 2011.).„NASA Researchers: DNA Building Blocks Can Be Made in Space”.NASA.Arhivirano izoriginalana datum 2020-05-11.Pristupljeno 10. 8. 2011.

[DNA-8] ScienceDaily Staff (9. 8. 2011.).„DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests”.ScienceDaily.Pristupljeno 9. 8. 2011.

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