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Mezokarb

Izvor: Wikipedija
Mezokarb
Klinički podaci
AHFS/Drugs Monografija
Identifikatori
CAS broj 34262-84-5
ATC kod nije dodeljen
PubChem[1][2] 71932
ChemSpider[3] 16736988
UNII UMT8MP2NDUDaY
Hemijski podaci
Formula C18H18N4O2
Mol. masa 322,361
SMILES eMolekuli&PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Mezokarbjeorgansko jedinjenje,koje sadrži 18atomaugljenikai imamolekulsku masuod 322,361Da.

Osobine

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Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 1
Broj rotacionih veza 5
Particioni koeficijent[4](ALogP) 4,7
Rastvorljivost[5](logS,log(mol/L)) -4,8
Polarna površina[6](PSA,Å2) 78,2

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today15(23-24): 1052-7.DOI:10.1016/j.drudis.2010.10.003.PMID20970519.edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry4:217-241.DOI:10.1016/S1574-1400(08)00012-1.
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).„Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”.J Cheminform2(1): 3.DOI:10.1186/1758-2946-2-3.PMID20331846.edit
  4. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A102:3762-3772.DOI:10.1021/jp980230o.
  5. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488-1493.DOI:10.1021/ci000392t.PMID11749573.
  6. Ertl P., Rohde B., Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714-3717.DOI:10.1021/jm000942e.PMID11020286.

Literatura

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Spoljašnje veze

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