Atenolol
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| Clinical data | |
|---|---|
| Trade names | Tenormin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684031 |
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| Routes of administration | oral,Intravenous(IV) |
| Drug class | Selectiveβ1receptorantagonist |
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| Pharmacokineticdata | |
| Bioavailability | 40–50% |
| Protein binding | 6–16%[1] |
| Metabolism | Minimal[1] |
| Onset of action | IV:<5 minutes[1] Oral:<1 hour[1] |
| Eliminationhalf-life | 6–7 hours[1] |
| Duration of action | >24 hours[1] |
| Excretion | Urine(>85%IV,50% oral)[1] |
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| ECHA InfoCard | 100.044.941 |
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| Chirality | Racemic mixture |
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Atenolol (brand name:Tenormin)is abeta blockermedication which treats high blood pressure (hypertension), irregular heartbeats (arrhythmia) andangina.[2]
History and culture
[change|change source]Atenolol was patented in 1969 and approved for medical use in 1975.[3]It is on theWorld Health Organization's List of Essential Medicines.[4]It is available as ageneric medication.[5]In 2021, it was the 47th most commonly prescribed medication in the United States, with more than 14million prescriptions.[6][7][8]
Uses
[change|change source]For people with high blood pressure, taking atenolol (or otherbeta blockers) helps prevent futureheart disease,heart attacksandstrokes.It can also be used to prevent chest pain caused by angina. Atenolol is sometimes prescribed to preventmigrainesand help withanxiety.[2]
Action
[change|change source]Atenolol works by slowing down theheart rate,making it easier for thehearttopump bloodaround thebody.[2]
Related pages
[change|change source]References
[change|change source]- ↑1.01.11.21.31.41.51.6"DailyMed - TENORMIN- atenolol tablet".DailyMed.30 June 2021.Archivedfrom the original on 27 January 2022.Retrieved20 November2023.
- ↑2.02.12.2"Atenolol: medicine for high blood pressure and angina".nhs.uk.2022-04-06.Retrieved2024-05-29.
- ↑Fischer J, Ganellin CR (2006).Analogue-based Drug Discovery.John Wiley & Sons. p. 461.ISBN9783527607495.
- ↑World Health Organization(2021).World Health Organization model list of essential medicines: 22nd list (2021).Geneva: World Health Organization.hdl:10665/345533.WHO/MHP/HPS/EML/2021.02.
- ↑"Atenolol Monograph for Professionals".Drugs.com.AHFS.Archivedfrom the original on 18 April 2019.Retrieved23 December2018.
- ↑"The Top 300 of 2021".ClinCalc.Archivedfrom the original on 15 January 2024.Retrieved14 January2024.
- ↑"Atenolol - Drug Usage Statistics".ClinCalc.Retrieved14 January2024.
- ↑Source Wikipedia