ACPD
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| Nazivi | |
|---|---|
| Sistemski IUPAC naziv
1-Aminociklopentan-1,3-dikarboksilna kiselina[1] | |
| Identifikacija | |
| |
3D model (Jmol)
|
|
| Abrevijacija | ACPD |
| ChemSpider | |
| MeSH | 1-amino-1,3-dicarboxycyclopentane |
| RTECS | GY4060000(1S,3R) |
| |
| Svojstva | |
| C7H11NO4 | |
| Molarna masa | 173,17 g·mol−1 |
| Agregatno stanje | Beli kristali |
| 20 g dm-3 | |
| Rastvorljivostuetanol | 240 mg dm-3 |
| log P | -0,709 |
| Kiselost(pKa) | 2,112 |
| Baznost(pKb) | 11,885 |
| Izoelektrična tačka | 2,84 |
| Opasnosti | |
| GHS grafikoni | 
|
| GHS signalna reč | Warning |
| H302,H312,H315,H319,H332,H335 | |
| P261,P280,P305+351+338 | |
EU klasifikacija(DSD)
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 Xn
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| R-oznake | R20/21/22,R36/37/38 |
| S-oznake | S26,S36/37 |
Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanjematerijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj(šta je  ?)
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| Reference infokutije | |
1-Amino-1,3-dikarboksiciklopentan(ACPD) je hemijsko jedinjenje koje se vezuje zametabotropni glutamatni receptor(mGluR).[4]ACPD deluje kao mGluRagonist.On je krut analogneurotransmiteraglutamatakoji ne aktivirajonotropne glutamatne receptore.[5]ACPD može da indukujekonvulzijekodneonatalnihpacova.[6]
Reference
[уреди|уреди извор]- ^„1-amino-1,3-dicarboxycyclopentane - Compound Summary”.PubChem Compound.USA: National Center for Biotechnology Information. 25. 3. 2005. Identification and Related Records.Приступљено15. 10. 2011.
- ^Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today.15(23-24): 1052—7.PMID20970519.doi:10.1016/j.drudis.2010.10.003.
- ^Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry.4:217—241.doi:10.1016/S1574-1400(08)00012-1.
- ^Schoepp DD, True RA (1992).„1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes”.Neurosci. Lett.145(1): 100—4.PMID1461560.doi:10.1016/0304-3940(92)90213-Q.
- ^Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”.Mol. Pharmacol.38(1): 1—6.PMID2164627.
- ^McDonald JW, Fix AS, Tizzano JP, Schoepp DD (1993).„Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”.J. Neurosci.13(10): 4445—55.PMID8410197.
