Amfonelinska kiselina
Изглед
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Klinički podaci | |
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Drugs.com | acid.html Monografija |
Identifikatori | |
CAS broj | 15180-02-6![]() |
ATC kod | none |
PubChem | CID2137 |
ChemSpider | 2052![]() |
UNII | RR302AR19Y![]() |
KEGG | D02897![]() |
ChEMBL | CHEMBL35337![]() |
Hemijski podaci | |
Formula | C18H16N2O3 |
Molarna masa | 308,331 |
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Amfonelinska kiselinajeorgansko jedinjenje,koje sadrži 18atomaugljenikai imamolekulsku masuod 308,331Da.
Osobine
[уреди|уреди извор]Osobina | Vrednost |
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Broj akceptora vodonika | 5 |
Broj donora vodonika | 1 |
Broj rotacionih veza | 4 |
Particioni koeficijent[1](ALogP) | 2,9 |
Rastvorljivost[2](logS,log(mol/L)) | -4,3 |
Polarna površina[3](PSA,Å2) | 70,5 |
Reference
[уреди|уреди извор]- ^Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A.102:3762—3772.doi:10.1021/jp980230o.
- ^Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488—1493.PMID11749573.doi:10.1021/ci000392t.
- ^Ertl P.; Rohde B.; Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714—3717.PMID11020286.doi:10.1021/jm000942e.
Literatura
[уреди|уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001).Goodman & Gilman's The Pharmacological Basis of Therapeutics(10. изд.). New York: McGraw-Hill.ISBN0071354697.doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007).Foye's Principles of Medicinal Chemistry(6. изд.). Baltimore: Lippincott Willams & Wilkins.ISBN0781768799.