Metabolička N-oksidacija amino-trimetilamina (TMA) iz hrane je posredovanamonooksigenazomkoja sadrži flavin. Ovaj gen ispoljava nasledni FMO3 polimorfizam kod ljudi koji rezultira u maloj potpopulaciji sa umanjenom TMA N-oksidacionom sposobnošću, posledica čega je sindrom zadaha ribe,trimetilaminurija.Tri forme ovog enzima, FMO1 u fetalnoj jetri, FMO2 u jetri odraslih osoba, i FMO3 su kodirani genima koji su grupisani u 1q23-q25 regionu. Monooksigenze koje sadržeflavinsuNADPHzavisni flavoenzimi koji katalizuju oksidacijunukleofilnihheteroatomskih centeraksenobiotikakao što supesticidiilekovi.[5]
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^„Mouse PubMed Reference:”.National Center for Biotechnology Information, U.S. National Library of Medicine.
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Itagaki K, Carver GT, Philpot RM (1996). „Expression and characterization of a modified flavin-containing monooxygenase 4 from humans”.J. Biol. Chem.271(33): 20102—7.PMID8702731.doi:10.1074/jbc.271.33.20102.
Janmohamed A, Dolphin CT, Phillips IR, Shephard EA (2001). „Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450”.Biochem. Pharmacol.62(6): 777—86.PMID11551524.doi:10.1016/S0006-2952(01)00718-3.
Furnes B, Feng J, Sommer SS, Schlenk D (2003). „Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans”.Drug Metab. Dispos.31(2): 187—93.PMID12527699.doi:10.1124/dmd.31.2.187.
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