Katepsin B
| Katepsin B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.22.1 | ||||||||
| CAS broj | 9047-22-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| StrukturePBP | RCSB PDBPDBePDBjPDBsum | ||||||||
| |||||||||
Katepsin B(EC3.4.22.1,katepsin B1,katepsin II) jeenzim.[1][2][3][4][5]Ovaj enzimkatalizujesledećuhemijsku reakciju
- Hidrolizaproteina sa širokom specifičšću za peptidne veze. Preferentno dolazi do razlaganja -Arg-Arg- veza u malim molekulskim supstratima (po čeme se razlikuje odkatepsina L).
Ovaj intraćelijski (lizozomalni) enzim pripada peptidaznoj familiji C1 (papainskoj familiji)
Reference
[уреди|уреди извор]- ^Bond, J.S. & Barrett, A.J. (1980).„Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase”.Biochem. J.189:17—25.PMID7458901.
- ^Barrett, A.J. & Kirschke, H. (1981). „Cathepsin B, cathepsin H and cathepsin L”.Methods Enzymol.80:535—561.PMID7043200.
- ^Polgár, L. and Csoma, C. (1987). „Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B”.J. Biol. Chem.262:14448—14453.PMID3312190.
- ^Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). „Lysosomal cysteine proteinases”.ISI Atlas of Science. Biochemistry.1:256—260.
- ^Kirschke, H., Wikstrom, P. and Shaw, E. (1988). „Active center differences between cathepsins L and B: the S1 binding region”.FEBS Lett.228:128—130.PMID3342870.
Literatura
[уреди|уреди извор]- Nicholas C. Price; Lewis Stevens (1999).Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins(Third изд.). USA: Oxford University Press.ISBN019850229X.
- Eric J. Toone (2006).Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution(Volume 75 изд.). Wiley-Interscience.ISBN0471205036.
- Branden C; Tooze J.Introduction to Protein Structure.New York, NY: Garland Publishing.ISBN0-8153-2305-0.
- Irwin H. Segel.Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems(Book 44 изд.). Wiley Classics Library.ISBN0471303097.
- William P. Jencks (1987).Catalysis in Chemistry and Enzymology.Dover Publications.ISBN0486654605.
Spoljašnje veze
[уреди|уреди извор]- Cathepsin+BнаUS National Library of Medicine Medical Subject Headings(MeSH)
