MTEP
 | |
| IUPACime | |
|---|---|
3-[(2-metil-1,3-tiazol-4-il)etinil]piridin | |
| Identifikatori | |
| CAS broj | 329205-68-7 |
| ATC kod | none |
| PubChem | CID9794218 |
| Hemijski podaci | |
| Formula | C11H8N2S |
| Molarna masa | 200,260 g/mol |
| |
3-[(2-Metil-4-tiazolil)etinil]piridin(MTEP) je lek koji se koristi u naučnim istraživanjima. Razvila ga je kompanijaMerck & Co..On je selektivanalosteranantagonistmetabotropnog glutamatnog receptoramGluR5.On je identifikovan putem studijaodnosa strukture i aktivnostistarijeg mGluR5 antagonistaMPEP.[1]MTEP je naknadno korišten kaovodeće jedinjenjeza novije i potentnije lekiva.[2][3]
Reference
[уреди|уреди извор]- ^Cosford ND; Tehrani L; Roppe J; et al. (2003). „3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity”.J. Med. Chem.46(2): 204—6.PMID12519057.doi:10.1021/jm025570j.
- ^Iso Y; Grajkowska E; Wroblewski JT; et al. (2006). „Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications”.J. Med. Chem.49(3): 1080—100.PMID16451073.doi:10.1021/jm050570f.
- ^Kulkarni SS, Newman AH (2007).„Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists”.Bioorg. Med. Chem. Lett.17(11): 2987—91.PMC1973162
.PMID17446071.doi:10.1016/j.bmcl.2007.03.066.
