Parametason
(преусмерено саParametazon)
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetičkipodaci | |
| Izlučivanje | Renalno |
| Identifikatori | |
| CAS broj | 53-33-8 |
| ATC kod | H02AB05(WHO) |
| PubChem | CID5875 |
| DrugBank | DB01384 |
| ChemSpider | 5664 |
| KEGG | C07413 |
| ChEMBL | CHEMBL1579 |
| Hemijski podaci | |
| Formula | C22H29FO5 |
| Molarna masa | 392,47 g·mol−1 |
| |
| |
Parametasonjefluorinisaniglukokortikoidsaantiinflamatornimiimunosupresivnimsvojstvima.[1]
Osobine
[уреди|уреди извор]Parametason jeorgansko jedinjenje,koje sadrži 22atomaugljenikai imamolekulsku masuod 392,461Da.[2][3]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 5 |
| Broj donora vodonika | 3 |
| Broj rotacionih veza | 2 |
| Particioni koeficijent[4](ALogP) | 1,4 |
| Rastvorljivost[5](logS,log(mol/L)) | -4,0 |
| Polarna površina[6](PSA,Å2) | 94,8 |
Reference
[уреди|уреди извор]- ^Toxnet:Paramethasone
- ^Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011).„DrugBank 3.0: a comprehensive resource for omics research on drugs”.Nucleic Acids Res.39(Database issue): D1035—41.PMC3013709
.PMID21059682.doi:10.1093/nar/gkq1126.
- ^David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008).„DrugBank: a knowledgebase for drugs, drug actions and drug targets”.Nucleic acids research.36(Database issue): D901—6.PMC2238889 .PMID18048412.doi:10.1093/nar/gkm958.
- ^Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A.102:3762—3772.doi:10.1021/jp980230o.
- ^Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488—1493.PMID11749573.doi:10.1021/ci000392t.
- ^Ertl P.; Rohde B.; Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714—3717.PMID11020286.doi:10.1021/jm000942e.
Literatura
[уреди|уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001).Goodman & Gilman's The Pharmacological Basis of Therapeutics(10. изд.). New York: McGraw-Hill.ISBN0071354697.doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007).Foye's Principles of Medicinal Chemistry(6. изд.). Baltimore: Lippincott Willams & Wilkins.ISBN0781768799.
Spoljašnje veze
[уреди|уреди извор]
 | Molimo Vas, obratite pažnju navažno upozorenje u vezi sa temama izoblasti medicine (zdravlja). |
