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Propilnorapomorfin

С Википедије, слободне енциклопедије
Propilnorapomorfin
IUPACime
(6aS)-6-propil-5,6,6a,7-tetrahidro-4H-dibenzo[de,g]hinolin-10,11-diol
Klinički podaci
Način primeneOralno
Pravni status
Pravni status
  • Uncontrolled
Identifikatori
CAS broj57559-68-9ДаY
ATC kodnone
PubChemCID5311191
ChemSpider4470712
Hemijski podaci
FormulaC19H21NO2
Molarna masa295,38 g/mol
  • CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O

N-n-Propilnorapomorfin(NPA) je derivataporfinakoji deluje kaodopaminski agonist.On je blisko srodan saapomorfinom.[1][2]Pokazano je da kod glodara između ostalog proizvodihiperaktivnost,stereotipiju,hipotermiju,antinocepciju,ierekciju.[3][4][5][6]

  1. ^Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain”.European Journal of Pharmacology.35(1): 77—83.PMID943290.doi:10.1016/0014-2999(76)90302-2.
  2. ^Creese I, Padgett L, Fazzini E, Lopez F (1979). „3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors”.European Journal of Pharmacology.56(4): 411—2.PMID477735.doi:10.1016/0014-2999(79)90274-7.
  3. ^Menon MK, Clark WG, Neumeyer JL (1978).„Comparison of the dopaminergic effects of apomorphine and (-)-N-n-propylnorapomorphine”.European Journal of Pharmacology.52(1): 1—9.PMID569056.doi:10.1016/0014-2999(78)90015-8.
  4. ^Riffee WH, Wilcox RE, Smith RV (1979). „Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice”.European Journal of Pharmacology.54(3): 273—7.PMID570924.doi:10.1016/0014-2999(79)90086-4.
  5. ^Neumeyer JL; Reinhard JF; Dafeldecker WP; et al. (1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine”.Journal of Medicinal Chemistry.19(1): 25—9.PMID942751.doi:10.1021/jm00223a006.
  6. ^Benassi-Benelli A, Ferrari F, Quarantotti BP (1979). „Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats”.Archives Internationales De Pharmacodynamie Et De Thérapie.242(2): 241—7.PMID44457.