S-18986
 | |
| IUPACime | |
|---|---|
(S)-2,3-dihidro-[3,4]ciklopentano-1,2,4-benzotiadiazin-1,1-dioksid | |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| ATC kod | none |
| PubChem | CID637863 |
| Hemijski podaci | |
| Formula | C10H12N2O2S |
| Molarna masa | 224,279 g/mol |
| |
S-18986jeampakinskilek koji je srodan saciklotiazidom.On ima nootropne ineuroprotektivneefekte u životinjskim studijama. S-18986 indukuje pojavuBDNFiAMPAposredovanog otpuštanjanoradrenalinaiacetilholinauhipokampusuifrontalnom korteksumozga.[1][2][3][4][5][6][7][8][9][10]
Reference
[уреди|уреди извор]- ^Lockhart B, Iop F, Closier M, Lestage P (2000). „(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices”.European Journal of Pharmacology.401(2): 145—53.PMID10924919.doi:10.1016/S0014-2999(00)00433-7.
- ^Lebrun C, Pillière E, Lestage P (2000). „Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats”.European Journal of Pharmacology.401(2): 205—12.PMID10924928.doi:10.1016/S0014-2999(00)00429-5.
- ^Dicou E, Rangon CM, Guimiot F, Spedding M, Gressens P (2003). „Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain”.Brain Research.970(1-2): 221—5.PMID12706264.doi:10.1016/S0006-8993(03)02357-6.
- ^Rosi S, Giovannini MG, Lestage PJ, Muñoz C, Corte LD, Pepeu G (2004). „S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat”.Neuroscience Letters.361(1-3): 120—3.PMID15135908.doi:10.1016/j.neulet.2003.12.061.
- ^Bourasset F, Bernard K, Muñoz C, Genissel P, Scherrmann JM (2005). „Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat”.Drug Metabolism and Disposition: the Biological Fate of Chemicals.33(8): 1137—43.PMID15860654.doi:10.1124/dmd.105.004424.
- ^Béracochéa D, Philippin JN, Meunier S, Morain P, Bernard K (2007).„Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil”.Psychopharmacology.193(1): 63—73.PMID17384936.doi:10.1007/s00213-007-0765-4.
- ^Marighetto A, Valerio S, Jaffard R, Mormede C, Muñoz C, Bernard K, Morain P (2008). „The AMPA modulator S 18986 improves declarative and working memory performances in aged mice”.Behavioural Pharmacology.19(3): 235—44.PMID18469541.doi:10.1097/FBP.0b013e3282feb0c1.
- ^Kelly SJ, Bernard K, Muñoz C, Lawrence RC, Thacker J, Grillo CA, Piroli GG, Reagan LP (2009).„Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats”.Psychopharmacology.202(1-3): 225—35.PMID18762915.doi:10.1007/s00213-008-1301-x.
- ^Gupta SK, Mishra R, Kusum S, Spedding M, Meiri KF, Gressens P, Mani S (2009). „GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986”.Cell Death and Differentiation.16(4): 624—37.PMID19136940.doi:10.1038/cdd.2008.188.
- ^Destot-Wong KD, Liang K, Gupta SK, Favrais G, Schwendimann L, Pansiot J, Baud O, Spedding M, Lelièvre V, Mani S, Gressens P (2009). „The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis”.Neuropharmacology.57(3): 277—86.PMID19501111.doi:10.1016/j.neuropharm.2009.05.010.
Vidi još
[уреди|уреди извор]
 | Molimo Vas, obratite pažnju navažno upozorenje u vezi sa temama izoblasti medicine (zdravlja). |
