5-HT1Dreceptor

5-hidroksitriptaminski (serotoninski) receptor 1D
Identifikatori
Simboli	HTR1D;5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
Vanjski ID	OMIM:182133MGI:96276HomoloGene:20240IUPHAR:5-HT1DGeneCards:HTR1D Gene
Ontologija gena Molekularna funkcija •aktivnost rodopsinu-sličnog receptora •receptorska aktivnost •aktivnost serotoninskog receptora Celularna komponenta •integralno sa ćelijskom membranom •membrana Biološki proces •prenos signala •G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom •sinaptička transmisija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3352	15552
Ensembl	ENSG00000179546	ENSMUSG00000070687
UniProt	P28221	Q3ZB48
RefSeq (mRNA)	NM_000864	NM_008309
RefSeq (protein)	NP_000855	NP_032335
Lokacija (UCSC)	Chr 1: 23.39 - 23.39 Mb	Chr 4: 135.7 - 135.72 Mb
PubMedpretraga	[1]	[2]

5-HT_1Dreceptor(5-hidroksitriptaminski (serotoninski) receptor 1D,HTR1D) je5-HT receptor.On je kodiran istoimenimgenom.5-HT_1Ddeluje nacentralni nervni sistem,i utiče na kretanje ianksioznost.On takoše indukuje vaskularnuvazokonstrikcijuu mozgu.

Ligandi

Agonisti

• 5-(Noniloksi)triptamin,
• sumatriptan(vazokonstriktorkodmigraine)
• 5-Karboksamidotriptamin(5-CT)
• 5-(t-Butil)-N-metiltriptamin
• CP-286,601
• PNU-109,291 ((S)-3,4-Dihidro-1-[2-[4-(4-metoksifenil)-1-piperazinil]etil]-N-metil-1H-2-benzopiran-6-karboksamid)
• PNU-142,633 ((1S)-1-[2-[4-[4-(Aminokarbonil)fenil]-1-piperazinil]etil]-3,4-dihidro-N-metil-1H-2-benzopiran-6-karboksamid)
• GR-46611 (3-[3-(2-Dimetilaminoetil)-1H-indol-5-il]-N-(4-metoksibenzil)akrilamid)
• L-694,247 (2-[5-[3-(4-Metilsulfonilamino)benzil-1,2,4-oksadiazol-5-il]-1H-indol-3-il]etanamin)
• L-772,405

Antagonisti

• Ziprasidon(atipični antipsihotik)
• metiotepin(antipsihotik)
• johimbin(afrodizijak)
• metergolin
• ergotamin(vazokonstriktorkodmigraine)
• BRL-15572
• GR-127,935 (mešoviti 5-HT_1B/1Dantagonist)
• LY-310,762
• LY-367,642
• LY-456,219
• LY-456,220

Vidi još

• 5-HT₁receptor
• 5-HT receptor

Dodatna literatura

• Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). „Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.”.Biochem. Biophys. Res. Commun.184(2): 752—9.PMID1315531.doi:10.1016/0006-291X(92)90654-4.
• Weinshank RL; Zgombick JM; Macchi MJ; et al. (1992).„Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.”.Proc. Natl. Acad. Sci. U.S.A.89(8): 3630—4.PMC48922 .PMID1565658.doi:10.1073/pnas.89.8.3630.
• Hamblin MW, Metcalf MA (1991). „Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.”.Mol. Pharmacol.40(2): 143—8.PMID1652050.
• Libert F; Passage E; Parmentier M; et al. (1992). „Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.”.Genomics.11(1): 225—7.PMID1662665.doi:10.1016/0888-7543(91)90125-X.
• Libert F; Parmentier M; Lefort A; et al. (1989). „Selective amplification and cloning of four new members of the G protein-coupled receptor family.”.Science.244(4904): 569—72.PMID2541503.doi:10.1126/science.2541503.
• Cargill M; Altshuler D; Ireland J; et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes.”.Nat. Genet.22(3): 231—8.PMID10391209.doi:10.1038/10290.
• Salim K; Fenton T; Bacha J; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.”.J. Biol. Chem.277(18): 15482—5.PMID11854302.doi:10.1074/jbc.M201539200.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99(26): 16899—903.PMC139241 .PMID12477932.doi:10.1073/pnas.242603899.
• Bergen AW; van den Bree MB; Yeager M; et al. (2004). „Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.”.Mol. Psychiatry.8(4): 397—406.PMID12740597.doi:10.1038/sj.mp.4001318.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14(10B): 2121—7.PMC528928 .PMID15489334.doi:10.1101/gr.2596504.
• Rual JF; Venkatesan K; Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”.Nature.437(7062): 1173—8.PMID16189514.doi:10.1038/nature04209.
• Gregory SG; Barlow KF; McLay KE; et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”.Nature.441(7091): 315—21.PMID16710414.doi:10.1038/nature04727.
• Li J; Zhang X; Wang Y; et al. (2007). „The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.”.Am. J. Med. Genet. B Neuropsychiatr. Genet.141(8): 874—6.PMID17099886.doi:10.1002/ajmg.b.30364.

Spoljašnje veze

• „5-HT_1D”.IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Архивирано изоригинала22. 02. 2012. г.