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Alnespiron

С Википедије, слободне енциклопедије
Alnespiron
IUPACime
(+)-4-dihidro-2H-hromen-3-il]-propilamino]butil]-8-azaspiro[4.5]dekan-7,9-dion
Identifikatori
CAS broj143413-68-7ДаY
ATC kodnone
PubChemCID178132
ChemSpider8002134ДаY
UNII34E28BM822ДаY
Hemijski podaci
FormulaC26H38N2O4
Molarna masa442,589 g/mol
  • Cl.O=C1N(C(=O)CC2(C1)CCCC2)CCCCN([C@H]3Cc4c(OC)cccc4OC3)CCC
  • InChI=1S/C26H38N2O4.ClH/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26;/h8-10,20H,3-7,11-19H2,1-2H3;1H/t20-;/m0./s1ДаY
  • Key:QYFHCFNBYQZGKW-BDQAORGHSA-NДаY

Alnespiron(S-20,499) jeselektivnipun agonist5-HT1Areceptoraizazapironskehemijske klase.[1][2][3]On imaantidepresivneianksiolitičkeefekte.[1]

  1. ^абGriebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J (1992). „Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.”.Neuroreport.3(1): 84—86.PMID1351756.doi:10.1097/00001756-199201000-00022.
  2. ^Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J (1992).„5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.”.Psychopharmacology (Berl).108(1-2): 47—50.PMID1357709.doi:10.1007/BF02245284.
  3. ^Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G (2003). „In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.”.Eur J Pharmacol.459(1): 17—26.PMID12505530.doi:10.1016/S0014-2999(02)02814-5.