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Bcl-2

С Википедије, слободне енциклопедије
B-ćelijski CLL/limfom 2
PDBprikaz bazairan na1GJH​,1G5M​.
Dostupne strukture
1G5M​,1GJH​,1YSW​,2O21​,2O22​,2O2F​,2W3L​,2XA0​
Identifikatori
Simboli BCL2;Bcl-2; PPP1R50
Vanjski ID OMIM:151430MGI:88138HomoloGene:527GeneCards:BCL2 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 596 12043
Ensembl ENSG00000171791 ENSMUSG00000057329
UniProt P10415 Q4VBF6
RefSeq (mRNA) NM_000633.2 NM_009741.3
RefSeq (protein) NP_000624.2 NP_033871.2
Lokacija (UCSC) Chr 18:
60.79 - 60.99 Mb		 Chr 1:
108.43 - 108.61 Mb
PubMedpretraga [1] [2]

Bcl-2(B-ćelijski limfom 2) je članBcl-2 familijeproteinskih regulatoraapoptoze.On je kodiranBCL2genom.[1][2]Bcl-2 je drugi član niza proteina koji su inicijalno bili opisani u kontekstuhromozomske translokacijehromozoma14 i 18 kodfolikularnih limfoma.Bcl-2ortolozi[3]postoje kod mnogobrojnihsisara.Dve izoforme Bcl-2, Izoforma 1, takođe poznata kao 1G5M, i Izoforma 2, poznata kao 1G5O/1GJH, imaju sličnu prostornu strukturu. Međutim, one se razlikuju u njihovoj sposobnosti vezivanjaBADuBAKproteina, kao i po strukturnoj topologiji i elektrostatičkom potencijalu vezujućeg žljeba. Iz toga sledi da Bcl-2 izoforme imaju različite antiapoptotičke aktivnosti.[4]

Interakcije

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Bcl-2 formirainterakcijesaRAD9A,[5]BAK1,[6][7]Retikulon 4,[8]Bcl-2 asocirani X protein,[5][6][9][10]Kaspaza 8,[11][12]BECN1,[13]SOD1,[14]Bcl-2 interagujući ubica,[15][16]BH3 interagujući domen agonista umiranja,[15][17]RRAS,[18]C-Raf,[19]BCL2L11,[15][20][21]BNIPL,[22][23]HRK,[15][24]PSEN1,[25]BMF,[26]BNIP2,[22][27]BNIP3,[27][28]Faktor rasta nerva IB,[6]BCL2-sličan 1,[6][29]Myc,[30]BCAP31,[31]SMN1,[32]CAPN2,[33]PPP2CA,[34]Noxa,[15][35]Cdk1,[36][37]TP53BP2,[38]Bcl-2 vezan promoter smrti[15][39]iIRS1.[40]

Ljudski BCL-2 geni

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BAK,BAK1,BAX,BCL2,BCL2A1,BCL2L1,BCL2L10,BCL2L13,BCL2L14,BCL2L2,BCL2L7P1,BOK,MCL1,LGALS7 (Galektin-7)

Reference

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Spoljašnje veze

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Bcl-2наВикимедијиној остави.
Преузето из „https://sr.wikipedia.org/w/index.php?title=Bcl-2&oldid=26730037”