CBiPES
 | |
| Klinički podaci | |
|---|---|
| Drugs | Monografija |
| Identifikatori | |
| CAS broj | 856702-40-4 |
| ATC kod | none |
| PubChem | CID9864510 |
| ChemSpider | 8040202 |
| Hemijski podaci | |
| Formula | C21H19N3O2S |
| Molarna masa | 377,459 |
| |
| |
CBiPESje lek koji se koristi u naučnim istraživanjima koji deluje kao selektivnipozitivni alosterični modulatorzametabotropni glutamat receptorgrupe II podtipmGluR2.On ima potencijalnoantipsihotičneefekte na životinjskim modelima i koristi se za istraživanje uloge mGluR2receptora ušizofrenijii srodnim poremećajima.[1][2][3]
Osobine
[уреди|уреди извор]CBiPES jeorgansko jedinjenje,koje sadrži 21atomugljenikai imamolekulsku masuod 377,459Da.
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 6 |
| Particioni koeficijent[4](ALogP) | 3,1 |
| Rastvorljivost[5](logS,log(mol/L)) | -6,0 |
| Polarna površina[6](PSA,Å2) | 82,4 |
Reference
[уреди|уреди извор]- ^Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, et al. (април 2005).„Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)”.Psychopharmacology.179(1): 271—83.PMID15717213.S2CID2699540.doi:10.1007/s00213-004-2099-9.
- ^Fell MJ, Katner JS, Johnson BG, Khilevich A, Schkeryantz JM, Perry KW, Svensson KA (март 2010). „Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge”.Neuropharmacology.58(3): 632—9.PMID19951716.S2CID7262560.doi:10.1016/j.neuropharm.2009.11.014.
- ^Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, et al. (март 2013). „Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR”.Neuropharmacology.66:264—73.PMID22659090.S2CID42448364.doi:10.1016/j.neuropharm.2012.05.023.
- ^Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A.102:3762—3772.doi:10.1021/jp980230o.
- ^Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488—1493.PMID11749573.doi:10.1021/ci000392t.
- ^Ertl P.; Rohde B.; Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714—3717.PMID11020286.doi:10.1021/jm000942e.
Literatura
[уреди|уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001).Goodman & Gilman's The Pharmacological Basis of Therapeutics(10. изд.). New York: McGraw-Hill.ISBN0071354697.doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007).Foye's Principles of Medicinal Chemistry(6. изд.). Baltimore: Lippincott Willams & Wilkins.ISBN0781768799.
