Hem B

Hem B
Nazivi
	Drugi nazivi Gvožđe protoporfirin IX,; protohem IX
Identifikacija
CAS broj	14875-96-8;
3D model (Jmol)	interaktivna slika;
ChemSpider	16739950;
ECHA InfoCard	100.114.904
MeSH	Heme+b
PubChemC ID	444098;
	SMILES OC(=O)CC/C6=C(\C)/C=3/N=C6/C=C2/C(/CCC(O)=O)=C(/C)\C1=C\C5=N\C(=C/c4n([Fe]N12)c(C=3)c(C=C)c4C)C(\C=C)=C5\C; ; ; ; ; ;
Svojstva
Hemijska formula	C34H32O4N4Fe
Molarna masa	616,487
	Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanjematerijala (na 25 °C [77 °F], 100 kPa).
	verifikuj(šta je?)
	Reference infokutije

Hem B(haem B,protohem IX) je najrasprostanjenijihem.^[3]Hemoglobinimioglobinsu primeri transportnih molekulakiseonikakoji sadrže hem B. Familijaperoksidaznihenzima takođe sadrži hem B.COX-1^[4]^[5]iCOX-2^[6]enzimi (ciklooksugenaze) sadrže hem B u jednom od dva aktivna mesta.

Hem B je generalno vezan za okružujući matriks (apoprotein) putem jednekoordinatne vezeizmeđu gvožđa hema iaminokiselinskogbočnog lanca.

Hemoglobinimioglobinimaju koordinatnu vezu sa evoluciono konzerviranimhistidinom,doksintaza azot oksidaicitohrom P450imaju koordinacinu vezu sa evoluciono konzerviranimcisteinom.

Gvožđe proteina koji sadrže hem B je vazano za četiriazota porfirina(koji formiraju ravan) i jednim elektron donirajućim atomom proteina. Stoga je gvožđe obično u pentakoordiniranom stanju. Kad se kiseonik ili toksičniugljen-monoksidvežu, gvožđe postaje heksakoordinirano.

Reference

^Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today.15(23-24): 1052—7.PMID 20970519.doi:10.1016/j.drudis.2010.10.003.уреди
^Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry.4:217—241.doi:10.1016/S1574-1400(08)00012-1.
^Rae, T.; Goff, H. (1998). „The heme prosthetic group of lactoperoxidase. Structural characteristics of heme l and heme l-peptides”.The Journal of Biological Chemistry.273(43): 27968—27977.PMID 9774411.doi:10.1074/jbc.273.43.27968.
^Yokoyama C, Tanabe T (1989). „Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme”.Biochem. Biophys. Res. Commun.165(2): 888—94.PMID 2512924.doi:10.1016/S0006-291X(89)80049-X.
^Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (1991).„Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment”.FASEB J.5(9): 2304—12.PMID 1907252.
^Hla, T.; Neilson, K (1992).„Human Cyclooxygenase-2 cDNA”.Proceedings of the National Academy of Sciences.89(16): 7384—8.PMC49714 .PMID 1380156.doi:10.1073/pnas.89.16.7384.

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today.15(23-24): 1052—7.PMID 20970519.doi:10.1016/j.drudis.2010.10.003.уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry.4:217—241.doi:10.1016/S1574-1400(08)00012-1.

[3] Rae, T.; Goff, H. (1998). „The heme prosthetic group of lactoperoxidase. Structural characteristics of heme l and heme l-peptides”.The Journal of Biological Chemistry.273(43): 27968—27977.PMID 9774411.doi:10.1074/jbc.273.43.27968.

[pmid2512924-4] Yokoyama C, Tanabe T (1989). „Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme”.Biochem. Biophys. Res. Commun.165(2): 888—94.PMID 2512924.doi:10.1016/S0006-291X(89)80049-X.

[pmid1907252-5] Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (1991).„Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment”.FASEB J.5(9): 2304—12.PMID 1907252.

[pmid1380156-6] Hla, T.; Neilson, K (1992).„Human Cyclooxygenase-2 cDNA”.Proceedings of the National Academy of Sciences.89(16): 7384—8.PMC49714 .PMID 1380156.doi:10.1073/pnas.89.16.7384.

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