ICI-118,551

ICI-118,551
Nazivi
	IUPAC naziv 3-(izopropilamino)-1-[(7-metil-4-indanil)oksi]butan-2-ol
Identifikacija
CAS broj	72795-19-8;
3D model (Jmol)	interaktivna slika;
MeSH	ICI+118551
PubChemC ID	3682;
	SMILES CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O; ; ; ; ; ;
Svojstva
Hemijska formula	C17H27NO2
Molarna masa	277,402 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanjematerijala (na 25 °C [77 °F], 100 kPa).
	verifikuj(šta je?)
	Reference infokutije

ICI-118,551je selektivniantagonist beta-2(β₂)adrenergičkog receptora.^[3]^[4]ICI se vezuje za β₂receptor sa više od sto puta većim afinitetom nego zaβ₁iliβ₃receptor.^[5]^[6]KompanijaImperijalne hemijske industrijeje razvila ovo jedinjenje.

Reference

^Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today.15(23-24): 1052—7.PMID 20970519.doi:10.1016/j.drudis.2010.10.003.уреди
^Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry.4:217—241.doi:10.1016/S1574-1400(08)00012-1.
^Hillman KL, Doze VA, Porter JE (2005).„Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus”.The Journal of Pharmacology and Experimental Therapeutics.314(2): 561—7.PMID 15908513.doi:10.1124/jpet.105.084947.
^Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). „A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors”.Journal of Pharmacological and Toxicological Methods.58(3): 189—97.PMID 18652905.doi:10.1016/j.vascn.2008.06.003.
^Mauriège P, De Pergola G, Berlan M, Lafontan M (1988).„Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists”.Journal of Lipid Research.29(5): 587—601.PMID 2900871.
^Emorine, L. J.; Marullo, S.; Briend-Sutren MM; et al. (1989). „Molecular characterization of the human beta 3-adrenergic receptor”.Science.245(4922): 1118—21.PMID 2570461.doi:10.1126/science.2570461.

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010).„PubChem as a public resource for drug discovery.”.Drug Discov Today.15(23-24): 1052—7.PMID 20970519.doi:10.1016/j.drudis.2010.10.003.уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.Annual Reports in Computational Chemistry.4:217—241.doi:10.1016/S1574-1400(08)00012-1.

[pmid15908513-3] Hillman KL, Doze VA, Porter JE (2005).„Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus”.The Journal of Pharmacology and Experimental Therapeutics.314(2): 561—7.PMID 15908513.doi:10.1124/jpet.105.084947.

[pmid18652905-4] Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). „A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors”.Journal of Pharmacological and Toxicological Methods.58(3): 189—97.PMID 18652905.doi:10.1016/j.vascn.2008.06.003.

[pmid2900871-5] Mauriège P, De Pergola G, Berlan M, Lafontan M (1988).„Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists”.Journal of Lipid Research.29(5): 587—601.PMID 2900871.

[pmid2570461-6] Emorine, L. J.; Marullo, S.; Briend-Sutren MM; et al. (1989). „Molecular characterization of the human beta 3-adrenergic receptor”.Science.245(4922): 1118—21.PMID 2570461.doi:10.1126/science.2570461.

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