Ifosfamid
Изглед
Klinički podaci | |
---|---|
Prodajno ime | Cyfos, Holoxan 1000, Ifex, Isoendoxan |
Drugs | Monografija |
Način primene | Intravenozno |
Farmakokinetičkipodaci | |
Poluvreme eliminacije | 7-15 h |
Izlučivanje | Renalno (70-86%) |
Identifikatori | |
CAS broj | 3778-73-2 |
ATC kod | L01AA06(WHO) |
PubChem | CID3690 |
DrugBank | DB01181 |
ChemSpider | 3562 |
KEGG | C07047 |
ChEBI | CHEBI:5864 |
ChEMBL | CHEMBL1024 |
Hemijski podaci | |
Formula | C7H15Cl2N2O2P |
Molarna masa | 261,086 |
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Fizički podaci | |
Tačka topljenja | 39—41 °C (102—106 °F) |
Ifosfamidjeorgansko jedinjenje,koje sadrži 7atomaugljenikai imamolekulsku masuod 261,086Da.[1][2][3][4][5][6][7][8][9][10][11][12]
Osobine
[уреди|уреди извор]Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 2 |
Broj donora vodonika | 1 |
Broj rotacionih veza | 5 |
Particioni koeficijent[13](ALogP) | 0,1 |
Rastvorljivost[14](logS,log(mol/L)) | -1,1 |
Polarna površina[15](PSA,Å2) | 51,4 |
Reference
[уреди|уреди извор]- ^Furlanut M, Franceschi L: Pharmacology of ifosfamide. Oncology. 2003;65 Suppl 2:2-6.PMID14586139
- ^Fleming RA: An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy. 1997 Sep-Oct;17(5 Pt 2):146S-154S.PMID9322882
- ^Wagner T: Ifosfamide clinical pharmacokinetics. Clin Pharmacokinet. 1994 Jun;26(6):439-56.PMID8070218
- ^Allen LM, Creaven PJ, Nelson RL: Studies on the human pharmacokinetics of isophosphamide (NSC-109724). Cancer Treat Rep. 1976 Apr;60(4):451-8.PMID1277221
- ^Brade WP, Herdrich K, Varini M: Ifosfamide--pharmacology, safety and therapeutic potential. Cancer Treat Rev. 1985 Mar;12(1):1-47.PMID3896483
- ^Zalupski M, Baker LH: Ifosfamide. J Natl Cancer Inst. 1988 Jun 15;80(8):556-66.PMID3286879
- ^Willits I, Price L, Parry A, Tilby MJ, Ford D, Cholerton S, Pearson AD, Boddy AV: Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer. Br J Cancer. 2005 May 9;92(9):1626-35.PMID15827549
- ^Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6.PMID16702183
- ^Schoenike SE, Dana WJ: Ifosfamide and mesna. Clin Pharm. 1990 Mar;9(3):179-91.PMID2107997
- ^Dechant KL, Brogden RN, Pilkington T, Faulds D: Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs. 1991 Sep;42(3):428-67.PMID1720382
- ^Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011).„DrugBank 3.0: a comprehensive resource for omics research on drugs”.Nucleic Acids Res.39(Database issue): D1035—41.PMC3013709 .PMID21059682.doi:10.1093/nar/gkq1126.
- ^David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008).„DrugBank: a knowledgebase for drugs, drug actions and drug targets”.Nucleic acids research.36(Database issue): D901—6.PMC2238889 .PMID18048412.doi:10.1093/nar/gkm958.
- ^Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A.102:3762—3772.doi:10.1021/jp980230o.
- ^Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488—1493.PMID11749573.doi:10.1021/ci000392t.
- ^Ertl P.; Rohde B.; Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714—3717.PMID11020286.doi:10.1021/jm000942e.
Literatura
[уреди|уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001).Goodman & Gilman's The Pharmacological Basis of Therapeutics(10. изд.). New York: McGraw-Hill.ISBN0071354697.doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007).Foye's Principles of Medicinal Chemistry(6. изд.). Baltimore: Lippincott Willams & Wilkins.ISBN0781768799.
Spoljašnje veze
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