Melfalan
Изглед
Klinički podaci | |
---|---|
Prodajno ime | Alkeran, L-PAM, L-Phenylalanine mustard, L-Sarcolysin |
Drugs | Monografija |
Način primene | Oralno |
Farmakokinetičkipodaci | |
Poluvreme eliminacije | 1,5 h |
Identifikatori | |
CAS broj | 148-82-3 |
ATC kod | L01AA03(WHO) |
PubChem | CID4053 |
DrugBank | DB01042 |
ChemSpider | 405297 |
ChEBI | CHEBI:28876 |
ChEMBL | CHEMBL852 |
Hemijski podaci | |
Formula | C13H18Cl2N2O2 |
Molarna masa | 305,200 |
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Fizički podaci | |
Tačka topljenja | 1.825 °C (3.317 °F) |
Melfalanjeorgansko jedinjenje,koje sadrži 13atomaugljenikai imamolekulsku masuod 305,200Da.[1][2][3][4][5]
Osobine
[уреди|уреди извор]Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 4 |
Broj donora vodonika | 2 |
Broj rotacionih veza | 8 |
Particioni koeficijent[6](ALogP) | -0,1 |
Rastvorljivost[7](logS,log(mol/L)) | -4,0 |
Polarna površina[8](PSA,Å2) | 66,6 |
Reference
[уреди|уреди извор]- ^Loeber R, Michaelson E, Fang Q, Campbell C, Pegg AE, Tretyakova N: Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem Res Toxicol. 2008 Apr;21(4):787-95. Epub 2008 Feb 14.PMID18324787
- ^Souliotis VL, Dimopoulos MA, Episkopou HG, Kyrtopoulos SA, Sfikakis PP: Preferential in vivo DNA repair of melphalan-induced damage in human genes is greatly affected by the local chromatin structure. DNA Repair (Amst). 2006 Aug 13;5(8):972-85. Epub 2006 Jun 15.PMID16781199
- ^Moscow JA, Swanson CA, Cowan KH: Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. Br J Cancer. 1993 Oct;68(4):732-7.PMID8398701
- ^Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011).„DrugBank 3.0: a comprehensive resource for omics research on drugs”.Nucleic Acids Res.39(Database issue): D1035—41.PMC3013709 .PMID21059682.doi:10.1093/nar/gkq1126.
- ^David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008).„DrugBank: a knowledgebase for drugs, drug actions and drug targets”.Nucleic acids research.36(Database issue): D901—6.PMC2238889 .PMID18048412.doi:10.1093/nar/gkm958.
- ^Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998).„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”.J. Phys. Chem. A.102:3762—3772.doi:10.1021/jp980230o.
- ^Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001).„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Chem Inf. Comput. Sci.41:1488—1493.PMID11749573.doi:10.1021/ci000392t.
- ^Ertl P.; Rohde B.; Selzer P. (2000).„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”.J. Med. Chem.43:3714—3717.PMID11020286.doi:10.1021/jm000942e.
Literatura
[уреди|уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001).Goodman & Gilman's The Pharmacological Basis of Therapeutics(10. изд.). New York: McGraw-Hill.ISBN0071354697.doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007).Foye's Principles of Medicinal Chemistry(6. изд.). Baltimore: Lippincott Willams & Wilkins.ISBN0781768799.
Spoljašnje veze
[уреди|уреди извор]
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