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(WKP)Q110226399
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(OCoLC)Q110226399
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David R. Jones
‡c
pharmacology researcher at Indiana University
‡9
en
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670
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‡a
Author's A phase I and pharmacokinetic trial of erlotinib in combination with weekly docetaxel in patients with taxane-naive malignancies.
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670
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‡a
Author's A phase I dose escalation and pharmacokinetic study of vatalanib
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670
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‡a
Author's A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors
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670
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‡a
Author's A Phase I Trial of High-Dose Clofarabine, Etoposide, and Cyclophosphamide and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Primary Refractory and Relapsed and Refractory Non-Hodgkin Lymphoma
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670
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‡a
Author's A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.
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670
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‡a
Author's A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic
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670
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‡a
Author's Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity
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670
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‡a
Author's ATPS-75TARGETING THE Mdm2-Akt SIGNALING NETWORK IN COMBINATION WITH TEMOZOLOMIDE IMPROVES EFFICACY IN ECTOPIC AND ORTHOTOPIC PATIENT-DERIVED GLIOBLASTOMA XENOGRAFT MODELS.
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670
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‡a
Author's Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2.
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670
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‡a
Author's Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers
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670
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‡a
Author's Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist
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670
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‡a
Author's Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.
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670
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‡a
Author's Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment
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670
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‡a
Author's Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5).
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670
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‡a
Author's Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.
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670
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‡a
Author's CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer
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670
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‡a
Author's Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance
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670
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‡a
Author's Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil
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670
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‡a
Author's Differential modulation of UDP-glucuronosyltransferase 1A1
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670
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‡a
Author's Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
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670
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‡a
Author's Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
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670
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‡a
Author's Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation
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670
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‡a
Author's Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes
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670
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‡a
Author's EXTH-13. REDUCTION OF TUMOR BURDEN AND HEARING LOSS WITH A MULTIPLE RECEPTOR TYROSINE KINASE INHIBITOR BRIGATINIB IN A GENETICALLY ENGINEERED MOUSE MODEL OF NEUROFIBROMATOSIS TYPE 2
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670
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‡a
Author's Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity
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670
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‡a
Author's Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth
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670
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‡a
Author's In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs
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670
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‡a
Author's In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles
|
670
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‡a
Author's In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies
|
670
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‡a
Author's Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats
|
670
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‡a
Author's Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice
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670
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‡a
Author's Mechanism-based inactivation of CYP3A by HIV protease inhibitors
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670
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‡a
Author's Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients
|
670
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‡a
Author's Pharmacokinetics of Cefepime in Patients with Cancer and Febrile Neutropenia in the Setting of Hematologic Malignancies or Hematopoeitic Cell Transplantation.
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670
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‡a
Author's Phase I, pharmacogenomic, drug-interaction study of sorafenib and bevacizumab in combination with paclitaxel in patients with advanced refractory solid tumors
|
670
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‡a
Author's Population pharmacokinetics of cefepime in febrile neutropenia: implications for dose-dependent susceptibility and contemporary dosing regimens.
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670
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‡a
Author's Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.
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670
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‡a
Author's Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites
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670
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‡a
Author's Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition
|
670
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‡a
Author's Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial
|
670
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‡a
Author's Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry
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670
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‡a
Author's Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples
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670
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‡a
Author's Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis
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670
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‡a
Author's Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.
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670
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‡a
Author's Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis
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670
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‡a
Author's Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome
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670
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‡a
Author's Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo
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670
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‡a
Author's Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS
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670
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‡a
Author's Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity
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670
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‡a
Author's The cytochrome P450 2B6
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670
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‡a
Author's The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
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670
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‡a
Author's The quantification of erlotinib (OSI-774) and OSI-420 in human plasma by liquid chromatography-tandem mass spectrometry
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670
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‡a
Author's Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer
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670
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‡a
Author's Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis
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919
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‡a
phase1trialofhighdoseclofarabineetoposideandcyclophosphamideandautologousperipheralbloodstemcelltransplantationinpatientswithprimaryrefractoryandrelapsedandrefractorynonhodgkinlymphoma
‡A
A Phase I Trial of High-Dose Clofarabine, Etoposide, and Cyclophosphamide and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Primary Refractory and Relapsed and Refractory Non-Hodgkin Lymphoma
‡9
1
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919
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‡a
phase1doseescalationandpharmacokineticstudyofvatalanib
‡A
A phase I dose escalation and pharmacokinetic study of vatalanib
‡9
1
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919
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‡a
phase1andpharmacokinetictrialoferlotinibincombinationwithweeklydocetaxelinpatientswithtaxanenaivemalignancies
‡A
A phase I and pharmacokinetic trial of erlotinib in combination with weekly docetaxel in patients with taxane-naive malignancies.
‡9
1
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919
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‡a
phase1doseescalationandpharmacokineticstudyofvatalanibptk787zk222584incombinationwithpaclitaxelinpatientswithadvancedsolidtumors
‡A
A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors
‡9
1
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919
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‡a
virtualscreeningtargetingtheurokinasereceptorbiochemicalandcellbasedstudiessynthesispharmacokineticcharacterizationandeffectonbreasttumormetastasis
‡A
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis
‡9
1
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919
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‡a
tissuetransglutaminaseactivatescancerassociatedfibroblastsandcontributestogemcitabineresistanceinpancreaticcancer
‡A
Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer
‡9
1
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919
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‡a
quantificationoferlotinibosi774andosi420inhumanplasmabyliquidchromatographytandemmassspectrometry
‡A
The quantification of erlotinib (OSI-774) and OSI-420 in human plasma by liquid chromatography-tandem mass spectrometry
‡9
1
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919
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‡a
cytochromep4502b6cyp2b6isthemaincatalystofefavirenzprimaryandsecondarymetabolismimplicationforhivaidstherapyandutilityofefavirenzasasubstratemarkerofcyp2b6catalyticactivity
‡A
The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
‡9
1
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919
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‡a
cytochromep4502b6
‡A
The cytochrome P450 2B6
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1
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919
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tamoxifendoseescalationinpatientswithdiminishedcyp2d6activitynormalizesendoxifenconcentrationswithoutincreasingtoxicity
‡A
Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity
‡9
1
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919
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‡a
stereoselectivemethodtoquantifybupropionandits3majormetaboliteshydroxybupropionerythrodihydrobupropionandthreodihydrobupropionusinghplcmsms
‡A
Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS
‡9
1
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919
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‡a
stereoselectiveglucuronidationofbupropionmetabolitesinvitroandinvivo
‡A
Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo
‡9
1
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919
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‡a
stereoselectiveanalysisofmethadoneandeddpinlaboringwomenandneonatesinplasmaanddriedbloodspotsandassociationwithneonatalabstinencesyndrome
‡A
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome
‡9
1
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919
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‡a
smallmoleculeinhibitionoftheuparupainteractionsynthesisbiochemicalcellularinvivopharmacokineticsandefficacystudiesinbreastcancermetastasis
‡A
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis
‡9
1
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919
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‡a
semiphysiologicallybasedpharmacokineticmodelsfortheinhibitionofmidazolamclearancebydiltiazemanditsmajormetabolite
‡A
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.
‡9
1
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919
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‡a
relationshipbetweendifferentialhepaticmicrornaexpressionanddecreasedhepaticcytochromep4503aactivityincirrhosis
‡A
Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis
‡9
1
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919
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‡a
relationshipamonghistologicradiologicandbiochemicalassessmentsofhepaticsteatosisastudyofhumanliversamples
‡A
Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples
‡9
1
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919
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‡a
quantificationofvincristineanditsmajormetaboliteinhumanplasmabyhighperformanceliquidchromatographytandemmassspectrometry
‡A
Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry
‡9
1
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919
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‡a
quantificationoftamoxifenand3metabolitesinplasmabyhighperformanceliquidchromatographywithfluorescencedetectionapplicationtoaclinicaltrial
‡A
Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial
‡9
1
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919
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‡a
predictionoftheeffectoferythromycindiltiazemandtheirmetabolitesaloneandincombinationoncyp3a4inhibition
‡A
Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition
‡9
1
|
919
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‡a
predictionofcytochromep4503ainhibitionbyverapamilenantiomersandtheirmetabolites
‡A
Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites
‡9
1
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919
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‡a
preclinicalassessmentsofthemekinhibitorpd0325901inamousemodelofneurofibromatosistype1
‡A
Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.
‡9
1
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919
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‡a
populationpharmacokineticsofcefepimeinfebrileneutropeniaimplicationsfordosedependentsusceptibilityandcontemporarydosingregimens
‡A
Population pharmacokinetics of cefepime in febrile neutropenia: implications for dose-dependent susceptibility and contemporary dosing regimens.
‡9
1
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919
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‡a
phase1pharmacogenomicdruginteractionstudyofsorafenibandbevacizumabincombinationwithpaclitaxelinpatientswithadvancedrefractorysolidtumors
‡A
Phase I, pharmacogenomic, drug-interaction study of sorafenib and bevacizumab in combination with paclitaxel in patients with advanced refractory solid tumors
‡9
1
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919
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‡a
pharmacokineticsofcefepimeinpatientswithcancerandfebrileneutropeniainthesettingofhematologicmalignanciesorhematopoeiticcelltransplantation
‡A
Pharmacokinetics of Cefepime in Patients with Cancer and Febrile Neutropenia in the Setting of Hematologic Malignancies or Hematopoeitic Cell Transplantation.
‡9
1
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919
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‡a
pharmacokineticandpharmacodynamicalterationsintherouxenygastricbypassrecipients
‡A
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients
‡9
1
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919
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‡a
mechanismbasedinactivationofcyp3abyhivproteaseinhibitors
‡A
Mechanism-based inactivation of CYP3A by HIV protease inhibitors
‡9
1
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919
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‡a
ketotifenmodulatesmastcellchemotaxistokitligandbutdoesnotimpactmastcellnumbersdegranulationortumorbehaviorinneurofibromasofnf1deficientmice
‡A
Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice
‡9
1
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919
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‡a
inhibitionofcyp3abyerythromycininvitroinvivocorrelationinrats
‡A
Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats
‡9
1
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919
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‡a
invivodpp4inhibitiontoenhanceengraftmentofsingleunitcordbloodtransplantsinadultswithhematologicalmalignancies
‡A
In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies
‡9
1
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919
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‡a
invivoassessmentofthemetabolicactivityofcyp2d6diplotypesandalleles
‡A
In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles
‡9
1
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919
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‡a
invitroeffectofchlorambucilonhumangliomacelllinessf767andu87mgandhumanmicrovascularendothelialcellhmvecandendothelialprogenitorcellsecfcsinthecontextofplasmachlorambucilconcentrationsintumorbearingdogs
‡A
In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs
‡9
1
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919
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‡a
impactofape1ref1redoxinhibitiononpancreatictumorgrowth
‡A
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth
‡9
1
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919
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‡a
humanizedbonemarrowmousemodelasapreclinicaltooltoassesstherapymediatedhematotoxicity
‡A
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity
‡9
1
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919
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‡a
exth13reductionoftumorburdenandhearinglosswithamultiplereceptortyrosinekinaseinhibitorbrigatinibinageneticallyengineeredmousemodelofneurofibromatosistype2
‡A
EXTH-13. REDUCTION OF TUMOR BURDEN AND HEARING LOSS WITH A MULTIPLE RECEPTOR TYROSINE KINASE INHIBITOR BRIGATINIB IN A GENETICALLY ENGINEERED MOUSE MODEL OF NEUROFIBROMATOSIS TYPE 2
‡9
1
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919
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‡a
effectofcyp3a5expressiononvincristinemetabolismwithhumanlivermicrosomes
‡A
Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes
‡9
1
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919
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‡a
efavirenzprimaryandsecondarymetabolisminvitroandinvivoidentificationofnovelmetabolicpathwaysandcytochromep4502a6astheprincipalcatalystofefavirenz7hydroxylation
‡A
Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation
‡9
1
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919
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‡a
dualpi3kandwntpathwayinhibitionisasynergisticcombinationagainsttriplenegativebreastcancer
‡A
Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
‡9
1
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919
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‡a
differentialmodulationofudpglucuronosyltransferase1a1ugt1a1catalyzedestradiol3glucuronidationbytheadditionofugt1a1substratesandothercompoundstohumanlivermicrosomes
‡A
Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
‡9
1
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919
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‡a
differentialmodulationofudpglucuronosyltransferase1a1
‡A
Differential modulation of UDP-glucuronosyltransferase 1A1
‡9
1
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919
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‡a
differentialmechanismbasedinhibitionofcyp3a4andcyp3a5byverapamil
‡A
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil
‡9
1
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919
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‡a
dextromethorphantodextrorphanurinarymetabolicratiodoesnotreflectdextromethorphanoralclearance
‡A
Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance
‡9
1
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919
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‡a
cyp3a5genotypeanditsimpactonvincristinepharmacokineticsanddevelopmentofneuropathyinkenyanchildrenwithcancer
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CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer
‡9
1
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919
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‡a
contributionofnglucuronidationtoefavirenzeliminationinvivointhebasalandrifampininducedmetabolismofefavirenz
‡A
Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.
‡9
1
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919
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‡a
computationalapproachesthatpredictmetabolicintermediatecomplexformationwithcyp3a4+b5
‡A
Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5).
‡9
1
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919
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‡a
comprehensiveassessmentofcytochromesp450andtransportergeneticswithendoxifenconcentrationduringtamoxifentreatment
‡A
Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment
‡9
1
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919
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‡a
comparativemetaboliccapabilitiesofcyp3a4cyp3a5andcyp3a7
‡A
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.
‡9
1
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919
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‡a
combinationtherapyinaxenograftmodelofglioblastomaenhancementoftheantitumoractivityoftemozolomidebyanmdm2antagonist
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Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist
‡9
1
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919
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‡a
chiralplasmapharmacokineticsandurinaryexcretionofbupropionandmetabolitesinhealthyvolunteers
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Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers
‡9
1
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919
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‡a
chemopreventativecelecoxibfailstopreventschwannomaformationorsensorineuralhearinglossingeneticallyengineeredmurinemodelofneurofibromatosistype2
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Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2.
‡9
1
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919
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‡a
atps75targetingthemdm2aktsignalingnetworkincombinationwithtemozolomideimprovesefficacyinectopicandorthotopicpatientderivedglioblastomaxenograftmodels
‡A
ATPS-75TARGETING THE Mdm2-Akt SIGNALING NETWORK IN COMBINATION WITH TEMOZOLOMIDE IMPROVES EFFICACY IN ECTOPIC AND ORTHOTOPIC PATIENT-DERIVED GLIOBLASTOMA XENOGRAFT MODELS.
‡9
1
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919
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‡a
associationbetweennonalcoholichepaticsteatosisandhepaticcytochromep4503aactivity
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Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity
‡9
1
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919
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‡a
pilotstudyoftheimpactofgenotypeonnifedipinepharmacokineticswhenusedasatocolytic
‡A
A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic
‡9
1
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919
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‡a
phase2trialofdovitinibinbcgunresponsiveurothelialcarcinomawithfgfr3mutationsoroverexpressionhoosiercancerresearchnetworktrialhcrn12157
‡A
A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.
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