- Discovered sitting on her front porch in New York City and asked if she wanted to be in a movie. That movie was Kids (1995).
- She was homeless and lived in abandoned apartments virtually all of her adolescence.
- Is an alumna of the Lee Strasberg Institute, along with such actors as Frank Miranda, Mickey Rourke, Scarlett Johansson, Dennis Hopper and Julia Roberts.
- Is a huge fan of the Star Trek franchise, and even speaks broken Klingon language.
- Has an adopted daughter, Isabella Dawson. On a November 2021 Parent's Magazine "We are family" podcast, Rosario stated that her daughter, whom she adopted in 2014 at the age of 11, is named Isabella, and was never Lola. "I don't know where it came from, but somebody decided that her name was Lola and then everyone just kept running with it," the actress said.
- Rosario was raised in Manhattan. Rosario's mother, Isabel Celeste, is a writer and professional vocalist, who has Puerto Rican and Afro-Cuban ancestry. Rosario's biological father's name is Patrick C. Harris. Rosario's mother married Greg Dawson, a caucasian construction worker who raised Rosario and gave her his surname.
- Has her own production company called Trybe.
- Never knew her biological father. Her adoptive father Greg Dawson met Rosario's mother when she was eight months pregnant with her.
- Co-created the comic book "Occult Crimes Taskforce" (2006).
- Attended an alternative school in downtown Manhattan, where she harbored aspirations of one day becoming a marine biologist.
- Is a real-life train aficionado who travels on trains all over the world, wherever and whenever possible.
- Her uncle is comic book artist Gustavo Vazquez.
- Although she is relatively tall at 5"7", she is quite short compared to the rest of her family. Her mother is six feet tall, her father is six-feet three inches tall and her brother is nearly a foot taller than her at six-feet five inches.
- Her mother was sixteen when she gave birth to her.
- Attended and graduated from Garland High School in Garland, Texas.
- Her character from Rent (2005), Mimi, is modeled after the character Mimi in Giacomo Puccini's "La Boheme".
- Originally had a small role as a nurse in the horror film The Devil's Rejects (2005). Her character was cut out of the theatrical release after director Rob Zombie decided to remove the character Dr. Satan. Her character was to be killed off within forty seconds of her entrance.
- In a romantic relationship with Senator Cory Booker since December 2018, having first met at a political fundraiser for former NAACP president Ben Jealous.
- Is a huge fan of the webcomic "Homestuck".
- Has a younger brother: Clay Dawson.
- Her birthdate holds the record for the hottest May 9th ever in New York City at an approximate 97 degrees.
- Lives in Los Angeles.
- Supported Bernie Sanders in the 2016 U.S. Presidential Election.
- (November 9, 2006) Broke up with Jason Lewis.
- Daughter of Isabel Dawson.
- Her uncle is a teacher known as Uncle Frank or Mr. Jump
- Lives with Jason Lewis in Los Angeles, California. (November 2005)
- Has appeared as "Claire Temple" in Marvel's Marvel's Daredevil (2015), Jessica Jones (2015), Luke Cage (2016), Iron Fist (2017), and the crossover mini-series The Defenders (2017), but did not make an appearance in The Punisher (2017). However, Rob Morgan, who plays Turk Barrett did appear in every one of the MCU programs on Netflix.
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