The authors demonstrate a magnetic-field-controlled, on-off switchable non-reciprocal negative refractive index in a non-Hermitian photon-magnon hybrid system, highlighting the crucial role of non-Hermitian dynamics in advancing photonics and magnonics in quantum hybrid technologies.

The direct oxygenation of C–C bonds through single-oxygen-atom insertion like the Baeyer-Villiger reaction is of particular significance. Herein, the authors present an approach for the skeletal modification of styrene using O₂via oxygen insertion, resulting in the formation of aryl ether frameworks under mild reaction conditions.

Here the authors directly observe space-charge-induced electric fields at yttria-stabilized zirconia grain boundaries, revealing how space charge layers corelate with grain boundary orientations, core atomic structures, and yttrium segregation amounts.

Protein condensates underlie various cellular events. Here, the authors developed short peptide tags that form reversible amyloids, which enable the fabrication of artificial protein condensates with different fluidities or multi-component properties in mammalian cells.

N-glycosylation has a significant role in immunosuppressive tumor microenvironment (TME). Here, the authors design an injectable ROS-sensitive hydrogel scaffold co-delivering piezocatalyst BiFeO₃and glucose/mannose analog 2-deoxy-d-glucose alleviating N-glycosylation inhibition and thereby effectively stimulating immune responses within TME.

Surface water neodymium isotopes and rare earth element compositions reveal a marked impact from the January 2022 Hunga Tonga-Hunga Ha’apai eruption in the western South Pacific, with released trace metals potentially stimulating biological responses.

In this study, the authors show that the placement of protected areas is globally highly heterogenous but can be accurately predicted from a reduced set of socioeconomic and environmental factors. These predictions highlight that most unprotected areas critical for the conservation of vertebrates are located in unfavourable conditions to establish future protected areas.

Standard climate proxies cannot quantify sea surface temperatures below 4 °C. Here, temperature signals recorded in shells (Mg/Ca) of polar foraminifera are isolated to resolve past marine polar amplification and climate change accurately.

Mangrove-derived organic carbon (OC) contributes 49% and 62% to estuarine and marine mangrove soil OC (SOC). Globally, 1502 Tg and 3025 Tg SOC were stored in estuarine and marine mangroves.

Titanium concentrations in zircon crystals reveal a link between the world’s largest copper resources and magmas with very high-water contents.

Stochastic or genetic effects can drive variability in X-chromosome inactivation (XCI) ratios among mammals, though their relative contributions are poorly understood. This study measures distributions of XCI ratios for 10 species and finds the embryonic stochasticity of XCI is a general explanatory model for mammalian XCI ratio variability.

Theα7 nicotinic acetylcholine receptor plays important roles in the human nervous system. Here, authors use molecular simulations to develop a gating model and reveal cholesterol effects, offering insights applicable to drug design.

GPCRs are vital drug targets. Here, authors use HDX-MS to gain insight into structural dynamics of β1AR upon ligand binding, revealing agonist-induced destabilisation and antagonist stabilisation of ICL1.

The clinical outcomes of esophageal squamous cell carcinoma (ESCC) remain poor, and thus it remains critical to find prognostic molecular markers. Here, the authors identify prognostic ESCC subtypes based on bulk and single-cell RNA-seq combined with histology AI in samples from patients with more than four years of follow-up, and find markers associated with immune evasion.

In this work, authors probe the molecular mechanism of re-emerging CHL susceptibility in Malawian Enterobacterales isolates, where they identify a stable truncation of resistance genes by insertion sequences.

Neuroblastoma (NB) is a frequent childhood cancer that often becomes resistant to therapy. Here, the authors perform spatiotemporal genomic profiling of NBs before and after chemotherapy and find an evolutionary process characteristic of NBs growing resistant after first responding to treatment.

Here the authors show that the m¹G9 post-transcriptional methylation differentially regulates the stability of the native and the MELAS variants of human mt-Leu(UAA) tRNA, contributing to mitochondrial pathology.

The mechanisms connecting intraocular pressure to glaucoma remain unclear. Here, the authors use GWAS by subtraction to reveal intraocular pressure-independent aspects of glaucoma.

Gene drives have the potential to support malaria control by suppressing vector populations, but their impacts will depend on local ecology and epidemiology. Here, the authors incorporate location-specific data to model how gene drives could perform in sixteen diverse African settings.

Gain of function mutant CaV1.2 channels drive life-threatening hypoglycemia in the multisystem disorder Timothy syndrome, but the underlying mechanisms are unknown. Here the authors show the mutant channels have adverse effects on counterregulatory hormones and CNS control of glucose homeostasis.

When individuals meet hostile groups, they can choose whether to defend themselves or flee and leave others behind. Here, the authors show that pro-social preferences predict staying and defense, while leaving is predicted by concerns for personal costs and risk.

Six surveys show substantial public agreement with misinformation about wind farms. Agreement with diverse contrarian claims is best predicted by participants’ worldviews, most notably the tendency to believe conspiracy theories.

Plastic pollution can be dealt with advanced recycling and bio-based production. Best-case scenario would require 22 Mha of sugarcane areas in Brazil to meet the 2050 global biopolyethylene demand. However, this may require ecosystem trade-offs.

Unfairness in AI healthcare models arise from biased correlations between sensitive attributes and disease data. Here, the authors show that the Attribute Neutral Framework reduces these biases and enhances fairness without compromising diagnostic accuracy.

This paper proposes an open-source, impact-based forecast for tropical cyclone population displacement using both cyclone forecasts and population settlements and vulnerabilities. This is applied to Tropical Cyclone Yasa, striking Fiji in 2020.