macitentan (Q6724151)

Macitentan (English)

18 November 2016

CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

1 reference

https://www.whocc.no/atc_ddd_index/?code=C02KX04

Macitentan (English)

18 November 2016

10 milligram

route of administration

oral administration

1 reference

reference URL

1 reference

14 February 2018

World Health Organisation international non-proprietary name

macitentan (English)

1 reference

macitentan (English)

medical condition treated

3 October 2016

pulmonary embolism

1 reference

2 October 2018

pulmonary hypertension

1 reference

Portopulmonary hypertension

2 October 2018

1 reference

connective tissue disease

2 October 2018

1 reference

chronic pulmonary heart disease

2 October 2018

1 reference

Food and Drug Administration

2 October 2018

pulmonary hypertension

start time

18 October 2013

approved by

1 reference

Inxight: Drugs Database

https://drugs.ncats.io/drug/Z9K9Y9WMVL

2 November 2018

reference URL

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204410s008lbl.pdf

physically interacts with

Endothelin receptor type A

subject has role

antagonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Endothelin receptor type B

17 August 2016

subject has role

antagonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

17 August 2016

legal status (medicine)

boxed warning

1 reference

reference URL

imported from Wikimedia project

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

US pregnancy category X

1 reference

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Macitentan

last update

30 September 2017

subject has role

Endothelin B Receptor Antagonists

1 reference

Medical Subject Headings

MeSH descriptor ID

C533860

endothelin A receptor antagonists

15 March 2018

1 reference

InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)

Medical Subject Headings

15 March 2018

Macitentan

0 references

Identifiers

InChI

1 reference

Macitentan (English)

18 November 2016

2 references

Macitentan (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

441798-33-0

2 references

macitentan (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=441798-33-0

9 April 2021

1 reference

Macitentan (English)

18 November 2016

2 references

Macitentan (English)

18 November 2016

Reaxys registry number

11340634

1 reference

macitentan (English)

3 October 2016

mapping relation type

2 references

MACITENTAN (English)

18 November 2016

International Chemical Identifier

InChI

InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)

1 reference

MACITENTAN (English)

18 November 2016

2 references

inferred from InChIKey

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

1 reference

2 references

DSSTOX compound identifier

0 references

0 references

1 reference

MACITENTAN (English)

publication date

17 November 2015

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

macitentan (English)

18 November 2016

1 reference

Medical Subject Headings

14 March 2018

1 reference

macitentan (English)

18 November 2016

1 reference

2 references

macitentan (English)

18 November 2016

MedlinePlus drug identifier

0 references

1 reference

macitentan (English)

18 November 2016

0 references

1 reference

1 reference

macitentan (English)

3 October 2016

0 references

Microsoft Academic ID

0 references

1 reference